Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players
In conclusion, PCSK9 inhibition impairs systemic inflammation and endothelial dysfunction by constraining leukocyte-endothelium interactions. PCSK9 blockade may constitute a new therapeutic approach to control the inflammatory state associated with FH, preventing further cardiovascular events in this cardiometabolic disorder.PMID:34864314 | DOI:10.1016/j.biopha.2021.112460
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Patrice Marques Elena Domingo Arantxa Rubio Sergio Martinez-Herv ás Juan F Ascaso Laura Piqueras Jos é T Real Maria-Jesus Sanz Source Type: research