Dementia and Down’s Syndrome: The key link between Down’s Syndrome and Alzheimer’s

NOT EVERYONE with Down's Syndrome develops Alzheimer's, but around 50 percent of people with the disorder develop memory loss in their 50s and 60s. Why are people with Down's Syndrome at an increased risk of dementia?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Medical research and development in the context of aging has, like all other medicine, been dominated for a long time by a model in which a single disease is identified by symptoms and then treated. In the context of infectious disease and inherited conditions, this is a good way to go about the matter of investigation, treatment, and assignment of resources. A patient typically has one disease at a time, and the symptoms are distinct and clearly caused by the disease in question. Indeed, the disease paradigm arose from the modern era's long road towards ever more effective control of infectious disease. The institutions a...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
We report for the first time the development of a simple distance-based β-amyloid (Aβ) protein quantification on a paper-based device (dPAD) to screen and follow Alzheimer's disease (AD). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
TUESDAY, Jan. 25, 2022 -- Stability in body mass index (BMI) over time is associated with a better cognitive trajectory in older adults, according to a study published online Jan. 20 in Alzheimer's&Dementia. Michal Schnaider Beeri, Ph.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Condition:   Alzheimer Disease Intervention:   Behavioral: Perturbation training Sponsors:   Georgia State University;   Alzheimer's Association Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
For many of us, a car is a sign of independence. But this emotional connection to our automobiles is part of what makes convincing a person that he or she is no longer capable of driving such a volatile battle. The longer adult children or others wait to discuss driving issues with a loved one, the harder it can be. Occasionally, people in the earlier stages of cognitive or physical decline will recognize the signs of that decline when they have a close call while driving and scare themselves into giving up their right to drive. More frequently, if the person has developed Alzheimer’s or another type of dementia, and...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
It’s been known for years that women are more at risk for Alzheimer’s disease than men.  Now, there’s even more evidence of gender differences. A new study has found that among those who've been diagnosed with mild cognitive impairment (MCI), women show a much faster rate of memory loss than men. The 2015 Alzheimer’s Association International Conference took place recently in Washington, D.C. While many topics were covered, including some drugs that are showing promise, this study about women has attracted its share of attention. Earlier studies showing that more women developed ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Alzheimer’s disease is increasing at an alarming rate. There is currently no way to prevent or cure it, or even to slow its progression. Here are some important Alzheimer’s facts that everyone should know. What is Alzheimer’s Disease? Alzheimer’s disease is a form of dementia. Dementia is a brain disorder that impacts the ability to carry out daily activities. It is a degenerative disease that affects memory, thought, and language. It eventually progresses to the point where patients require 24-hour care. The disease always leads to death. The onset of Alzheimer’s disease usually happens after...
Source: Shield My Senior - Category: Geriatrics Authors: Tags: Senior Safety Source Type: blogs
Scientists at the University of Edinburgh’s Centre for Cognitive and Neural Systems have found evidence that long-term testing starting well before any signs of Alzheimer’s symptoms are evident could be a valuable tool in detecting which people will need intervention with therapeutic drugs that are now in clinical trials. This type of intervention could possibly halt or even reverse cognitive damage while the patient is still symptom-free. The long-term testing would be done in conjunction with brain scans. Read full article on HealthCentral about the value of long-term testing: Support a caregiver or jump star...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
The objective of this systematic review is to evaluate the published literature on longitudinal data in order to identify the cognitive and behavioural changes occurring during the prodromal and early stages of AD in this population . Fifteen peer-reviewed articles met the inclusion criteria, including a total number of 831 participants, with the duration between baseline and follow up varying from 1 year to 47 years. Results suggest that, compared to the general population for which short-term (episodic) memory loss is the m ost common indicator associated with the onset of AD, in people with DS, executive dysfu...
Source: Neuropsychology Review - Category: Neuroscience Source Type: research
Abstract Down syndrome (DS) is the most common non-lethal genetic condition that affects approximately 1 in 700 births in the United States of America. DS is characterized by complete or segmental chromosome 21 trisomy, which leads to variable intellectual disabilities, progressive memory loss, and accelerated neurodegeneration with age. During the last three decades, people with DS have experienced a doubling of life expectancy due to progress in treatment of medical comorbidities, which has allowed this population to reach the age when they develop early onset Alzheimer's disease (AD). Individuals with DS develo...
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
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