Probiotics on Intestinal Flora Disturbance and Bacterial Translocation in Mice with Inflammatory Bowel Disease

Liying Ding*, Xiuting Chen, K. Qian and Z. Jiang
Source: Indian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research

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Inflammatory bowel diseases (IBD) are chronic pathologies characterized by dysbiosis, defects in epithelial barrier function, and increased redox stress. Dysbiosis in IBD involves an expansion of Proteobacteria and a reduction of Firmicutes, which produce metabolites important in maintaining gut homeostasis. The epithelial NADPH oxidase dual oxidase 2 (DUOX2) catalyzes the production of hydrogen peroxide (H2O2) and is the only gene consistently altered in IBD patients in association with dysbiosis and before the onset of disease.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Epithelial Cell Biology/Function in Inflammation Source Type: research
Conclusions Our findings reveal a tripartite regulatory mechanism by which PTPN2 preserves macrophage antibacterial function, thus crucially contributing to host defence against invading bacteria.
Source: Gut - Category: Gastroenterology Authors: Tags: Open access, Gut Gut microbiota Source Type: research
Conclusion: Cinacalcet inhibits the activation of NF-κB and reduces the production of inflammatory cytokines by suppressing the PKCδ/ERK/P65 signaling pathway via targeting NK1R, suggesting that it can be used to treat inflammatory diseases, particularly colitis.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing of immunocytes to distant organ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
AbstractPurpose of ReviewThere is increasing evidence on the connections between chronic oral inflammation/infection and the pathophysiological conditions of the gastrointestinal tract and accessory organs of digestion. The aim of this review is to provide a critical synthesis regarding the epidemiological, clinical, and in vivo associations between periodontitis and the most relevant diseases of the digestive system.Recent FindingsAn increasing body of dental and medical literature is supporting the gum-gut axis as a relevant mechanism to explain the associations between periodontitis and systemic diseases. Indeed, shared...
Source: Current Oral Health Reports - Category: Dentistry Source Type: research
In conclusion, this study demonstrates that baicalein ameliorates colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s, thus providing a potential therapy for UC.PMID:34671110 | DOI:10.1038/s41401-021-00781-7
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research
This study aimed to investigate the of GRK2 in the pathogenesis of ulcerative colitis (UC) and its effects on macrophage polarization, macrophage subtype regulation of intestinal barrier function, and therapeutic effects of CP-25 in mice with DSS-induced colitis. We found imbalanced macrophage polarization, intestinal barrier dysfunction, and abnormal activation of GRK2 and TLR4-NF- κB-NLRP3 inflammasome signaling pathway in the colonic mucosa of patients with UC. CP-25, restored the damaged intestinal barrier function by inhibiting the transmembrane region of GRK2 in macrophages stimulated by lipopolysaccharides. CP...
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research
This article is categorized under: Infectious Diseases> Genetics/Genomics/Epigenetics Infectious Diseases> Molecular and Cellular Physiology
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - Category: Biomedical Science Authors: Tags: Advanced Review Source Type: research
The murine interleukin-4 treated macrophage (MIL4) exerts anti-inflammatory and pro-healing effects and has been shown to reduce the severity of chemical-induced colitis. Positing M(IL4) transfer as an anti-inflammatory therapy, the possibility of side-effects must be considered. Consequently, bone marrow-derived M(IL4)s were administered via intraperitoneal injection to mice concomitant with Citrobacter rodentium infection (infections colitis), azoxymethane/dextran sodium sulphate (AOM/DSS) treatment [a model of colorectal cancer (CRC)], or ovalbumin sensitization (airway inflammation). The impact of M(IL4) treatment...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study aimed to investigate the of GRK2 in the pathogenesis of ulcerative colitis (UC) and its effects on macrophage polarization, macrophage s ubtype regulation of intestinal barrier function, and therapeutic effects of CP-25 in mice with DSS-induced colitis. We found imbalanced macrophage polarization, intestinal barrier dysfunction, and abnormal activation of GRK2 and TLR4-NF-κB-NLRP3 inflammasome signaling pathway in the colonic mucosa of patients with UC. CP-25, restored the damaged intestinal barrier function by inhibiting the transmembrane region of GRK2 in macrophages stimulated by lipopolysaccharides. CP...
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research
More News: Drugs & Pharmacology | India Health | Inflammatory Bowel Disease | Probiotics | Translocation