Treatment Thresholds and ASCVD Risk Treatment Thresholds and ASCVD Risk

A new study reveals benefit to high-intensive statin therapy among very-high-risk patients, even if their baseline LDL-C levels are low.Journal of the American College of Cardiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

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ConclusionsPatients may be more likely to meet LDL-C targets while enrolled in CR compared to standard care. Following the introduction of lower absolute LDL-C targets and additional  >  50% LDL-C reduction from baseline requirement, fewer patients are meeting the LDL-C targets set out in the 2019 ESC dyslipidaemia guidelines. Additionally, many patients are not on maximum statin therapy, ezetimibe is under-prescribed, and a guideline-reimbursement gap exists for those who requir e PCSK9i therapy.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
This study aimed to determine the prevalence and clinical characteristics of anti-HMGCR antibodies in idiopathic inflammatory myositis (IIM) at a tertiary care centre in northern India. Data (adult and children) were retrieved from the MyoCite dataset, identifying patients with polymyositis, dermatomyositis, and antibody-negative IIM whilst fulfilling the ACR/EULAR criteria. SLE, sarcoidosis, and systemic sclerosis were included for comparison as disease controls. The baseline clinical profile, laboratory tests, and muscle biopsies were retrieved and analysed. Descriptive statistics and non-parametric statistics were used ...
Source: Rheumatology International - Category: Rheumatology Source Type: research
STATINS provide a buffer against heart disease by reducing the production of cholesterol in the liver. The effects of the cholesterol-lowering drugs are not entirely benign, however. Specific dietary interactions can induce unpleasant side effects. According to a BMJ review, "excessive" consumption of two fruits can intensify a painful side effect.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Am Fam Physician. 2022 Jan 1;105(1):65-72.ABSTRACTAtherosclerotic vascular disease is a leading cause of death worldwide. Atherosclerotic stenosis of the internal carotid or intracranial arteries causes up to 15% of strokes. Peripheral artery disease affects up to one in five people in the United States who are 60 years and older and nearly one-half of those who are 85 years and older. Renal artery stenosis may affect up to 5% of people with isolated hypertension and up to 40% of people with other atherosclerotic diseases. All patients with atherosclerotic vascular disease should receive a comprehensive program of guidelin...
Source: American Family Physician - Category: Primary Care Authors: Source Type: research
THURSDAY, Jan. 13, 2022 -- Statins appear to be safe to use during pregnancy, according to a study published online Dec. 30 in JAMA Network Open. Jui-Chun Chang, M.D., from Taichung Veterans General Hospital in Taiwan, and colleagues examined...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Int J Womens Dermatol. 2021 Sep 9;7(5Part A):560-575. doi: 10.1016/j.ijwd.2021.08.015. eCollection 2021 Dec.ABSTRACTFor patients with lupus erythematosus (LE) or dermatomyositis (DM), there is an urgent need to address a heightened risk of clinical events, chiefly heart attacks and strokes, caused by atherosclerotic cardiovascular disease (ASCVD). Patients with LE or DM frequently exhibit high levels of conventional risk factors for ASCVD events, particularly dyslipoproteinemia and hypertension; an amplified burden of atherosclerotic plaques; and increased age- and sex-adjusted rates of ASCVD events compared with the gener...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Clin Mol Hepatol. 2022 Jan 13. doi: 10.3350/cmh.2021.0366. Online ahead of print.ABSTRACTPreclinical studies highlighted potential therapeutic applications of aspirin and statins as anticancer agents based on their pleotropic effects. Epidemiologic studies suggested the role of aspirin and statins in the chemoprevention of hepatocellular carcinoma (HCC). However, observational data is prone to bias, and no prospective randomized trials are currently available to assess the risks and benefits of statin or aspirin therapy for chemoprevention of HCC. It is therefore important for clinicians and researchers to be aware of the ...
Source: Clinical and molecular hepatology - Category: Gastroenterology Authors: Source Type: research
CONCLUSIONS: Independent of co-medication use, current regular aspirin users had greater non-dense area with stronger estimates for women with higher BMI. We found limited support for an association between current aspirin use and mammographically dense breast tissue among parous women.PMID:35022893 | DOI:10.1007/s10552-021-01530-1
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Nature Reviews Cardiology, Published online: 13 January 2022; doi:10.1038/s41569-021-00670-wMeta-analyses and cardiovascular outcome trials are laying the foundation for seasonal influenza vaccines to be a mainstay in the prevention of cardiovascular disease, rivalling established measures such as statin therapy. In this Clinical Outlook, we highlight current and future approaches for the use of influenza vaccination to reduce the risk of atherosclerotic cardiovascular disease and heart failure.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research
By KIM BELLARD An essay in Aeon had me at the title: The Waste Age.  The title was so evocative of the world we live in that I almost didn’t need to read further, but I’m glad I did, and I encourage you to do the same.  Because if we don’t learn to deal with waste – and, as the author urges, design for it – our future looks pretty grim. Healthcare included. The essay is by Justin McGuirk, chief curator of the Design Museum in London, and accompanies an exhibit there: Waste Age: what can design do?  Mr. McGuirk states: …waste is not merely a byproduct of cu...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Policy Public Health Healthcare system Kim Bellard medical waste plastics Source Type: blogs
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