GSE99756 Transcriptome profiling of HepG2 cells in Cdc20 overexpressed and downregulated condition

Contributor : Susanta RoychoudhurySeries Type : Expression profiling by arrayOrganism : Homo sapiensCdc20 acts as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. Here we tried to explore the novel transcription regulatory function of Cdc20 by means of altering Cdc20 level in HepG2 cells. We transiently over expressed Flag tagged Cdc20 (F) and siRNA mediated knocked down Cdc20(S) in HepG2 cell line and performed whole genome microarray analysis using illumina BeadChip Array. Significantly altered genes were subjected to the analysed by Ingenuity pathway analysis software (Build version: 302937) and crucial cellcycle and apoptotic pathways were found to be altered. These pathways could further be explored as anticancer therapy in liver carcinoma.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

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Source: Asian Journal of Surgery - Category: Surgery Authors: Source Type: research
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Source: European Radiology - Category: Radiology Source Type: research
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Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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