30 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes

European Journal of Human Genetics, Published online: 06 December 2021; doi:10.1038/s41431-021-01011-830 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
Source: European Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Source Type: research

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Colon cancer screening rates have increased, but fully one-third of those over 50 aren’t screened.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
This study investigates the tumor growth suppression and antitumor effects of DCs primed with miR-155-enriched exosome on the BALB/c murine model of colorectal cancer induced by CT-26 cell lines. Therefore, a holistic framework is proposed for the analysis procedure. In the first stage, miRNA-155 was electroporated into texosomes. In the second stage, bonemarrow-derived DCs were treated with miRNA-155 enriched texosomes. Then, antitumor properties of manipulated DC have been evaluated in the BALB/c mice model of colorectal cancer. After DC immunotherapy, several features have been assessed for each animal, including surviv...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Pharmacol Res. 2022 Jan 12:106082. doi: 10.1016/j.phrs.2022.106082. Online ahead of print.ABSTRACTPatchouli Essential Oil (PEO) has been used as a scent for various healing purposes since the ancient Egyptian period. The primary source of the oil is Pogostemon cablin (PC), a medicinal plant for treating gastrointestinal symptoms. However, the pharmacological function has not been addressed. Here, we report the cancer prevention and gut microbiota (GM) modulating property of PEO and its derivatives patchouli alcohol (PA) and pogostone (PO) in the ApcMin/+ colorectal cancer mice model. We found that PEO, PA, and PO significa...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Eur J Epidemiol. 2022 Jan 15. doi: 10.1007/s10654-021-00834-5. Online ahead of print.ABSTRACTHow metabolome changes influence the early process of colorectal cancer (CRC) development remains unknown. We conducted a 1:2 matched nested case-control study to examine the associations of pre-diagnostic plasma metabolome (profiled using LC-MS) with risk of CRC precursors, including conventional adenomas (n = 586 vs. 1141) and serrated polyps (n = 509 vs. 993), in the Nurses' Health Study (NHS) and NHSII. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). We used the permutati...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: Recent trial results do not warrant de novo skepticism of metastasectomy nor targeted extracolonic surveillance. Given the potential for clinically meaningful life-expectancy gain and significant uncertainty, a trial of metastasectomy is needed.PMID:35031098 | DOI:10.1016/j.jval.2021.07.017
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
This study investigates the tumor growth suppression and antitumor effects of DCs primed with miR-155-enriched exosome on the BALB/c murine model of colorectal cancer induced by CT-26 cell lines. Therefore, a holistic framework is proposed for the analysis procedure. In the first stage, miRNA-155 was electroporated into texosomes. In the second stage, bonemarrow-derived DCs were treated with miRNA-155 enriched texosomes. Then, antitumor properties of manipulated DC have been evaluated in the BALB/c mice model of colorectal cancer. After DC immunotherapy, several features have been assessed for each animal, including surviv...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research
J Cancer Res Clin Oncol. 2022 Jan 15. doi: 10.1007/s00432-021-03889-9. Online ahead of print.ABSTRACTPURPOSE: A large number of studies have suggested an inhibitory role of estrogens against colorectal cancer (CRC), but persistent controversy exists. CRC characteristics are affected by sex, age, and tumor locus, suggesting the need for a systematic study considering these factors. The purpose of this study was to verify the difference in the pathobiological role of estrogens in CRC according to patient/tumor backgrounds.METHODS: Surgical specimens from 116 postmenopausal women (≥ 70 years/o, n = 74;
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
Clin Colorectal Cancer. 2021 Nov 18:S1533-0028(21)00119-5. doi: 10.1016/j.clcc.2021.11.001. Online ahead of print.ABSTRACTWith increased therapeutic options in rectal cancer, a central question has become how to tailor therapy to patient preferences to avoid both over and under treatment. Total Neoadjuvant Therapy (TNT), defined as delivering all planned chemotherapy and radiation therapy (RT) before surgery, was developed with the primary goal of improving overall survival through early elimination of micrometastatic disease. In this narrative review assessing patients with operable adenocarcinoma of the rectum, we sought...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
Biochem Pharmacol. 2022 Jan 12:114913. doi: 10.1016/j.bcp.2022.114913. Online ahead of print.ABSTRACTNitazoxanide and related thiazolides are a novel class of anti-infectious agents against protozoan parasites, bacteria and viruses. In recent years, it is demonstrated thatthiazolides also can induced cell cycle arrest and apoptotic cell death in cancer cells. Due to their fast proliferating nature, cancer cells highly depend on the proteasome system to remove aberrant proteins. Many of these aberrant proteins are regulators of cell cycle progression and apoptosis, such as the cyclins, BCL2 family members and nuclear factor...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
J Cancer Res Clin Oncol. 2022 Jan 15. doi: 10.1007/s00432-021-03889-9. Online ahead of print.ABSTRACTPURPOSE: A large number of studies have suggested an inhibitory role of estrogens against colorectal cancer (CRC), but persistent controversy exists. CRC characteristics are affected by sex, age, and tumor locus, suggesting the need for a systematic study considering these factors. The purpose of this study was to verify the difference in the pathobiological role of estrogens in CRC according to patient/tumor backgrounds.METHODS: Surgical specimens from 116 postmenopausal women (≥ 70 years/o, n = 74;
Source: Clin Med Res - Category: Research Authors: Source Type: research
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