Statins side effects: Signs of 'cognitive impairment' that may be associated with the drug

STATINS are one of the most commonly prescribed drugs in the UK by around 8 million adults. They became available in the late 1980s, and there have been several reported side effects.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Int J Vasc Med. 2022 Jan 6;2022:4224975. doi: 10.1155/2022/4224975. eCollection 2022.ABSTRACTPrevious studies have linked peripheral microvascular dysfunction measured by arterial tonometry to high residual risk in on-statin patients. Digital thermal monitoring (DTM) of microvascular function is a new and simplified technique based on fingertip temperature measurements that has been correlated with the burden of atherosclerosis and its risk factors. Here, we report analyses of DTM data from two large US registries: Registry-I (6,084 cases) and Registry-II (1,021 cases) across 49 US outpatient clinics. DTM tests were perfor...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
This study provides scientific rationale towards the therapeutic effect of Eucalyptus camaldulensis aqueous bark extract against induced atherosclerosis and hyperlipidemia in pigeons. Phytochemical components of Eucalyptus bark extract possess a great antioxidant activity that potentially reduced the risk of heart diseases. A total of 42 Pigeons of both sexes were distributed into negative control (fed normal grain diet), hyperlipidemic control (fed HFD 1% animal fat oil and 0.1% cholesterol for 3 months), test groups of variable doses (0.05, 0.1, 0.2 to 0.4 gms/kg BW for 21 days) and the group received atorvastatin daily ...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Int J Vasc Med. 2022 Jan 6;2022:4224975. doi: 10.1155/2022/4224975. eCollection 2022.ABSTRACTPrevious studies have linked peripheral microvascular dysfunction measured by arterial tonometry to high residual risk in on-statin patients. Digital thermal monitoring (DTM) of microvascular function is a new and simplified technique based on fingertip temperature measurements that has been correlated with the burden of atherosclerosis and its risk factors. Here, we report analyses of DTM data from two large US registries: Registry-I (6,084 cases) and Registry-II (1,021 cases) across 49 US outpatient clinics. DTM tests were perfor...
Source: International Journal of Vascular Medicine - Category: Cardiology Authors: Source Type: research
STATINS are a group of medicines used by patients to lower their levels of Low-Density Lipoprotein, otherwise known as colloquially as ‘bad' cholesterol. A lot like most medicines taking statins result in some side effects that can affect your eyes and cheekbones.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study aimed to determine the prevalence and clinical characteristics of anti-HMGCR antibodies in idiopathic inflammatory myositis (IIM) at a tertiary care centre in northern India. Data (adult and children) were retrieved from the MyoCite dataset, identifying patients with polymyositis, dermatomyositis, and antibody-negative IIM whilst fulfilling the ACR/EULAR criteria. SLE, sarcoidosis, and systemic sclerosis were included for comparison as disease controls. The baseline clinical profile, laboratory tests, and muscle biopsies were retrieved and analysed. Descriptive statistics and non-parametric statistics were used ...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: Statin treatment significantly lowers ADMA concentrations. This effect is independent of baseline cholesterol. Prospective studies are required to determine whether ADMA-lowering mediates, at least partly, the protective effects of statins against atherosclerotic cardiovascular disease. (PROSPERO registration number: CRD42021275123).PMID:35032642 | DOI:10.1016/j.niox.2022.01.001
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
ConclusionsPatients may be more likely to meet LDL-C targets while enrolled in CR compared to standard care. Following the introduction of lower absolute LDL-C targets and additional  >  50% LDL-C reduction from baseline requirement, fewer patients are meeting the LDL-C targets set out in the 2019 ESC dyslipidaemia guidelines. Additionally, many patients are not on maximum statin therapy, ezetimibe is under-prescribed, and a guideline-reimbursement gap exists for those who requir e PCSK9i therapy.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
This study aimed to determine the prevalence and clinical characteristics of anti-HMGCR antibodies in idiopathic inflammatory myositis (IIM) at a tertiary care centre in northern India. Data (adult and children) were retrieved from the MyoCite dataset, identifying patients with polymyositis, dermatomyositis, and antibody-negative IIM whilst fulfilling the ACR/EULAR criteria. SLE, sarcoidosis, and systemic sclerosis were included for comparison as disease controls. The baseline clinical profile, laboratory tests, and muscle biopsies were retrieved and analysed. Descriptive statistics and non-parametric statistics were used ...
Source: Rheumatology International - Category: Rheumatology Source Type: research
STATINS provide a buffer against heart disease by reducing the production of cholesterol in the liver. The effects of the cholesterol-lowering drugs are not entirely benign, however. Specific dietary interactions can induce unpleasant side effects. According to a BMJ review, "excessive" consumption of two fruits can intensify a painful side effect.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Am Fam Physician. 2022 Jan 1;105(1):65-72.ABSTRACTAtherosclerotic vascular disease is a leading cause of death worldwide. Atherosclerotic stenosis of the internal carotid or intracranial arteries causes up to 15% of strokes. Peripheral artery disease affects up to one in five people in the United States who are 60 years and older and nearly one-half of those who are 85 years and older. Renal artery stenosis may affect up to 5% of people with isolated hypertension and up to 40% of people with other atherosclerotic diseases. All patients with atherosclerotic vascular disease should receive a comprehensive program of guidelin...
Source: American Family Physician - Category: Primary Care Authors: Source Type: research
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