Dealing with uncertainty about the Omicron variant | David Spiegelhalter and Anthony Masters

Caution is sensible when so much is unknownThe race is on to understand the new variant identified by scientists inSouth Africa and Botswana, dubbedOmicron (the next Greek letter was “nu”, but this could have been mistaken for “new”). Fears include greater spread, worse disease or reduced effectiveness of treatments and vaccines.Increased transmission can arise from two factors. First, there is an intrinsic advantage, with a heightened “basic reproduction number” R0; in a susceptible population, that is the average number of people each case infects, although after 20 months of pandemic this has become a notional concept. It was around 3 for the original wild-type virus, compared to around 6 for Delta and possibly rather more for Omicron.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus South Africa Infectious diseases Science World news Source Type: news

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As with any other ineradicable disease, prevention and treatment can be integrated into societyDelaying and preventing infection as much as possible through this pandemic was a worthwhile strategy. In early 2020, there were few treatments, limited testing and no vaccines. The costs of those lockdowns were big, but the effort to buy time paid off. In that time, science has transformed Covid from a deadly virus to a much less serious, nasty disease – one that is manageable at home, for the vast majority of those vaccinated. It has, largely, defanged it.But even as we have had success treating and preventing serious inf...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus Infectious diseases Health Medical research Microbiology Science UK news Vaccines and immunisation Source Type: news
Treasury Secretary Janet Yellen has told a gathering of America’s mayors the Biden administration’s coronavirus relief bill is “like a vaccine” preventing catastrophic economic damage
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
British PMset to relax Plan B Covid measures, ending the use of vaccine certificates and work-from-home guidance; the narrative that Omicron is a mild disease is misleading, WHO saysPlan B Covid restrictions in England expected to ease after Cabinet meetingNicola Sturgeon announces lifting of Omicron restrictions in ScotlandCalls for French MP to resign after announcing Covid protocol from IbizaHong Kong to cull thousands of hamsters after Covid found on 11New Zealand closes borders to new arrivals over Omicron riskHello it ’s Samantha Lock with you on the blog today as we unpack all the latest Covid developments fro...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus UK news Boris Johnson Science World news Omicron variant World Health Organization Source Type: news
GENEVA>> The worst of the coronavirus pandemic — deaths, hospitalizations and lockdowns — could be over this year if huge inequities in vaccinations and medicines are addressed quickly, the head... #emergencies #worldhealthorganization
Source: Reuters: Health - Category: Consumer Health News Source Type: news
A leading World Health Organization official says the worst of the coronavirus pandemic — including deaths, hospitalizations and lockdowns — could be over this year if huge inequities in vaccinations and medicines are addressed quickly
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The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
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In this study, Metadichol® was found to be 270 times more potent an inhibitor of TMPRSS2 (EC50 = 96 ng/mL) than camostat mesylate (EC50 = 26000 ng/mL). Additionally, it inhibits ACE with an EC50 of 71 ng/mL, but it is a very weak inhibitor of ACE2 at an EC50 of 31 μg/mL. Furthermore, the live viral assay performed in Caco-2 cells revealed that Metadichol® inhibits SARS-CoV-2 replication at an EC90 of 0.16 μg/mL. Moreover, Metadichol® had an EC90 of 0.00037 μM, making it 2081 and 3371 times more potent than remdesivir (EC50 = 0.77 μM) and chloroquine (EC50 = 1.14 μM), respectively.PMID:35039793 | ...
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSION: These guidelines were developed by a BSR Task Force with a high LOA among panelists, based on the literature review of published studies and expert opinion for COVID-19 vaccination in IMRD patients. Noteworthy, in the pandemic period, up to the time of the review and the consensus process for this document, high-quality evidence was scarce. Thus, it is not a substitute for clinical judgment.PMID:35039077 | DOI:10.1186/s42358-022-00234-7
Source: Adv Data - Category: Epidemiology Authors: Source Type: research
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