Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation

ConclusionThis study reveals that SFKs activity transmits P2X7 receptor signaling to facilitate CSD propagation via glutamatergic pathway and promote neuroinflammation, which is of particular relevance to migraine.

http://link.springer.com/10.1186/s10194-021-01359-8

Source: The Journal of Headache and Pain - December 4, 2021 Category: Neurology Source Type: research