The conquest of lung cancer in Central Europe

Purpose of review Discussed the main approaches for lung control and point out differences among Central Europe and other countries. Recent findings Three main approaches exist: smoking ban, early computed tomography screening and access to novel therapies; major differences exist between Central Europe and some other countries. Summary A major effort will be needed from Central Europe countries in all three approaches; it will require strong involvement from the political authorities.
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: LUNG AND MEDIASTINUM: Edited by Robert Pirker and Caicun Zhou Source Type: research

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Lung cancer remains a major cause of preventable death and early diagnosis is critical to improving survival chances. The chest X-ray (CXR) remains the most common initial investigation, but clinical pathways need to support timely diagnosis through, where necessary, escalation of abnormal findings to ensure priority reporting and early CT scan.
Source: Radiography - Category: Radiology Authors: Source Type: research
AbstractBackgroundMetabolic tumour volume (MTV) measured on fluorodeoxyglucose F18 (FDG) positron emission tomography coupled with computed tomography (PET/CT) is a prognostic factor of advanced non-small cell lung cancer (NSCLC) treated by first-line immunotherapy. However, these tumours are often necrotic and the necrosis, which is hypometabolic in PET FDG, is not included in the MTV. The aim of this study was to evaluate the prognostic value of total tumour volume (TTV), adding necrotic tumour volume (NTV) to metabolic tumour volume (MTV).MethodsWe retrospectively included 65 patients with NSCLC treated with pembrolizum...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Eur J Nucl Med Mol Imaging. 2022 Jan 20. doi: 10.1007/s00259-022-05690-3. Online ahead of print.ABSTRACTPURPOSE: To investigate the surgical prognosis and efficacy of adjuvant therapy in non-small cell lung cancer (NSCLC) with occult lymph node metastasis (ONM) defined by positron emission tomography/computed tomography (PET/CT).METHODS: A total of 3537 NSCLC patients receiving surgical resection were included in this study. The prognosis between patients with ONM and evident nodal metastasis, ONM patients with and without adjuvant therapy was compared, respectively.RESULTS: ONM was associated with significantly better pro...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Condition:   Lung Cancer Intervention:   Procedure: Low-dose computed tomography of the chest Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministère de la Santé et des Solidarités;   National Cancer Institute, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
J Appl Clin Med Phys. 2022 Jan 19:e13502. doi: 10.1002/acm2.13502. Online ahead of print.ABSTRACTPURPOSE: Radiation-induced lung injury (RILI) is a common side effect in patients with non-small cell lung cancer (NSCLC) treated with radiotherapy. Minimizing irradiation into highly functional areas of the lung may reduce the occurrence of RILI. The aim of this study is to evaluate the feasibility and utility of hyperpolarized xenon-129 magnetic resonance imaging (MRI), an imaging tool for evaluation of the pulmonary function, to guide radiotherapy planning.METHODS: Ten locally advanced NSCLC patients were recruited. Each pat...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractThe patient was a 53-year-old man. His chief complaint was a cough and dyspnea on exertion. Computed tomography (CT) showed a 3-cm-diameter tumor in the right upper lobe with invasion from hilar lymph nodes to the superior vena cava, right main bronchus, and pulmonary artery. After being diagnosed with non-small cell lung cancer, the patient underwent preoperative induction radiochemotherapy. At surgery, right upper double sleeve lobe lobectomy was performed. The right main pulmonary artery was reconstructed using a pericardial conduit. CT 1  week after surgery showed impaired blood flow in the right pulmonary...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Am J Transl Res. 2021 Dec 15;13(12):13516-13523. eCollection 2021.ABSTRACTOBJECTIVE: To determine the short-term prognostic value of Computed Tomography (CT) perfusion parameters in patients with advanced non-small cell lung cancer (NSCLC) after chemotherapy.METHODS: A total of 60 patients with NSCLC who received concurrent radiotherapy and chemotherapy were enrolled. Before therapy, CT perfusion imaging was conducted to scan their local lesions. Then, the CT perfusion-associated parameters were recorded, and evaluated. According to the Response Evaluation Criteria in Solid Tumors (RECIST), 42 out of 60 patients had remiss...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Chest. 2022 Jan 12:S0012-3692(22)00035-6. doi: 10.1016/j.chest.2021.12.662. Online ahead of print.ABSTRACTLung cancer screening is slowly but steadily entering the realm of preventive health maintenance. Standardization of reporting of positive findings identified on screening low dose computed tomography (LDCT) scans, specifically lung nodules, is a key element of high quality lung cancer screening. The American College of Radiology developed the Lung-RADS system for this purpose. In addition to detailed categorization of lung nodules, Lung-RADS identifies Category S for other incidental findings identified on screening L...
Source: Chest - Category: Respiratory Medicine Authors: Source Type: research
Intern Med. 2022 Jan 13. doi: 10.2169/internalmedicine.8507-21. Online ahead of print.ABSTRACTA 69-year-old man with advanced non-small-cell lung cancer was treated with pembrolizumab for 4 months. Three months after pembrolizumab was discontinued, computed tomography showed enlargement of the pancreatic head, with hypoattenuating areas in the pancreatic head to body. On endoscopic ultrasonography, the entire pancreatic parenchyma was hypoechoic. Endoscopic retrograde cholangiopancreatography showed narrowing of the main pancreatic duct at the pancreatic head. Endoscopic ultrasound-guided fine-needle aspiration showed infl...
Source: Internal Medicine - Category: Internal Medicine Authors: Source Type: research
CONCLUSIONS: Incidental findings on CT from major trauma patients may provide a novel and sensitive way of tracking the virus. It is recommended that all major trauma units include a simple question on signs of COVID-19 to provide an early warning system for further waves.PMID:35022132 | PMC:PMC8673733 | DOI:10.1016/j.crad.2021.12.001
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
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