Suppression of P2X3 receptor-mediated currents by the activation of α < sub > 2A < /sub > -adrenergic receptors in rat dorsal root ganglion neurons

CONCLUSIONS: These results suggested that activation of α2A -ARs by DEX suppressed P2X3 receptor-mediated electrophysiological and behavioral activity via a Gi/o proteins and cAMP signaling pathway, which was a novel potential mechanism underlying analgesia of peripheral α2A -AR agonists.PMID:34862748 | DOI:10.1111/cns.13774
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research