Cytokine alterations in psoriasis: an updated review

Expert Rev Clin Immunol. 2021 Nov 30. doi: 10.1080/1744666X.2022.2011720. Online ahead of print.ABSTRACTINTRODUCTION: Psoriasis is a chronic immune-mediated disease affecting 125 million people globally. It is characterized by erythematous plaques in the skin, covered by silvery scales. However, non-cutaneous manifestations (e.g., joint symptoms in psoriatic arthritis) and a high prevalence of other immune-mediated diseases such as inflammatory bowel diseases reflect its systemic nature. So far, research on psoriasis pathogenesis has improved our knowledge of the roles of the immune system, and cytokines play significant roles in immune responses.AREAS COVERED: Herein, we review cytokine changes in psoriasis patients. Moreover, we will investigate the possible relationships between disease severity and cytokine profiles alongside describing cytokine alterations in psoriasis patients with other comorbidities. Lastly, we will discuss the biologics and their effects on cytokines in patients with psoriasis.EXPERT OPINION: : Psoriasis could develop various clinical types and clinical manifestations in people. It is an immune-mediated disease, and these manifestations are associated with different impaired cytokines. Imbalanced cytokine profiles could lead to abnormal keratinocytes, neovascularization, and inflammation in psoriasis patients. So, a better understanding of the cytokine roles can help one choose a specific cytokine-targeting biologic to treat psoriasis. Moreover, thes...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research

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The spondyloarthritides (SpA) are a group of overlapping chronic immune-mediated inflammatory diseases, the most common being psoriatic arthritis (PsA) and axial spondyloarthritis. Other, less common diseases within the SpA family include reactive arthritis, enteropathic arthritis and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis). Shared features include a propensity to affect the peripheral and axial skeleton through enthesitis and synovitis, cutaneous and/or nail psoriasis, uveitis, inflammatory bowel disease, the absence of rheumatoid factor and an increased frequency of HLA-B27 variants.
Source: Medicine - Category: Internal Medicine Authors: Tags: Spondyloarthropathies Source Type: research
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Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
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Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Uncontrolled Therapeutic Observations in Humans Using Biologic or Non-Biologic Agents Source Type: research
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Source: J Rheumatol - Category: Rheumatology Authors: Source Type: research
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Source: JAMA - Category: General Medicine Source Type: research
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