Ipatasertib plus paclitaxel for PIK3CA/AKT1/PTEN-altered hormone receptor-positive HER2-negative advanced breast cancer: primary results from cohort B of the IPATunity130 randomized phase 3 trial

ConclusionAdding ipatasertib to paclitaxel did not improve efficacy inPIK3CA/AKT1/PTEN-altered HR+  HER2-negative aBC. The ipatasertib–paclitaxel safety profile was consistent with each agent’s known adverse effects.Trial registration NCT03337724.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research