Promising Nutritional Fruits Against Cardiovascular Diseases: An Overview of Experimental Evidence and Understanding Their Mechanisms of Action

Vasc Health Risk Manag. 2021 Nov 23;17:739-769. doi: 10.2147/VHRM.S328096. eCollection 2021.ABSTRACTCardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality in both developed and developing countries, affecting millions of individuals each year. Despite the fact that successful therapeutic drugs for the management and treatment of CVDs are available on the market, nutritional fruits appear to offer the greatest benefits to the heart and have been proved to alleviate CVDs. Experimental studies have also demonstrated that nutritional fruits have potential protective effects against CVDs. The aim of the review was to provide a comprehensive summary of scientific evidence on the effect of 10 of the most commonly available nutritional fruits reported against CVDs and describe the associated mechanisms of action. Relevant literatures were searched and collected from several scientific databases including PubMed, ScienceDirect, Google Scholar and Scopus. In the context of CVDs, 10 commonly consumed nutritious fruits including apple, avocado, grapes, mango, orange, kiwi, pomegranate, papaya, pineapple, and watermelon were analysed and addressed. The cardioprotective mechanisms of the 10 nutritional fruits were also compiled and highlighted. Overall, the present review found that the nutritious fruits and their constituents have significant benefits for the management and treatment of CVDs such as myocardial infarction, hypertension, peripheral artery di...

Source: Atherosclerosis - December 3, 2021 Category: Cardiology Authors: Nur Zulaikha Azwa Zuraini Mahendran Sekar Yuan Seng Wu Siew Hua Gan Srinivasa Reddy Bonam Nur Najihah Izzati Mat Rani M Yasmin Begum Pei Teng Lum Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Source Type: research