Effects of NAC on Symptoms of CHR Patients

Condition:   Prodromal Schizophrenia Interventions:   Dietary Supplement: N-Acetylcysteine;   Dietary Supplement: Placebo Sponsor:   Centre for Addiction and Mental Health Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conclusions: With the caveat that only a small number of comparisons were available for the review on MI-pure interventions, the efficacy of MI in treating co-occurring psychosis and substance use disorder was heterogeneous and modest.PMID:34963202 | DOI:10.4088/JCP.21r13916
Source: Journal of Clinical Psychiatry - Category: Psychiatry Authors: Source Type: research
Conclusions: these findings underline on one side the beneficial effects of physical activity on cognitive function in healthy individuals in a preventive and curative key, while on the other side the importance of an adequate evaluation of psychological distress and personality characteristics associated with exercise addiction.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Dual disorder is a term applied to patients with an addictive disorder and other mental disorder. Epidemiological studies have established that dual disorders are an expectation rather than an exception. They are difficult to diagnose and treat and constitute a huge burden for both patients and their relatives and society. Current treatments are a combination of those needed to treat the addictive disorder with those focused on the co-occurring psychiatric disorder. Focusing specifically on schizophrenia, growing scientific evidence supports the existence of a shared vulnerability for substance use in these patients and th...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Adv Neurobiol. 2021;26:173-227. doi: 10.1007/978-3-030-77375-5_9.ABSTRACTOngoing research continues to add new elements to the emerging picture of involvement of astrocyte energy metabolism in the pathophysiology of major psychiatric disorders, including schizophrenia, mood disorders, and addictions. This review outlines what is known about the energy metabolism in astrocytes, the most numerous cell type in the brain, and summarizes the recent work on how specific perturbations of astrocyte bioenergetics may contribute to the neuropsychiatric conditions. The role of astrocyte energy metabolism in mental health and disease ...
Source: Adv Data - Category: Epidemiology Authors: Source Type: research
Conclusions: These findings provide novel insights concerning the genes, cell types, and pathways underlying persistent behavioral deficits induced by adolescent exposure to THC in a sex-specific manner, and highlight the connection between adolescent cannabis use and neuropsychiatric disorders in humans.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Condition:   Prodromal Schizophrenia Interventions:   Dietary Supplement: N-Acetylcysteine;   Dietary Supplement: Placebo Sponsor:   Centre for Addiction and Mental Health Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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