Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance

Cancer in neonates and infants is a rare but challenging entity. Treatment is complicated by marked physiological changes during the first year of life, excess rates of toxicity, mortality, and late effects. Dose optimisation of chemotherapeutics may be an important step to improving outcomes. Body size –based dosing is used for most anticancer drugs used in infants. However, dose regimens are generally not evidence based, and dosing strategies are frequently inconsistent between tumour types and treatment protocols.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research