Screening for cervical cancer: Choices & amp; dilemmas

Indian J Med Res. 2021 Dec 2. doi: 10.4103/ijmr.IJMR_857_20. Online ahead of print.ABSTRACTCervical cancer is the fourth most common cancer in women in the world. To eliminate cervical cancer by 2030, the World Health Organization has given the target of 70 per cent coverage of twice lifetime screening. A multitude of screening methods are available, including cytology, human papillomavirus (HPV) DNA testing and visual inspection tests. Precision tests, including molecular and protein biomarkers such as DNA methylation, p16 immunostaining, and HPV mRNA testing help to enhance specificity of the screening. Worldwide HPV DNA testing with or without cytology is used as a screening method of choice, while in resource-poor settings, visual inspection tests are recommended. The major hurdle is a uniform and systematic implementation with a recall method in the population. Besides, controversies still exist regarding strategies to manage HPV-positive women and developing guidelines to screen the vaccinated population.PMID:34854432 | DOI:10.4103/ijmr.IJMR_857_20
Source: The Indian Journal of Medical Research - Category: Biomedical Science Authors: Source Type: research

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AbstractIntroduction Human papillomavirus (HPV) vaccination uptake is lower among foreign-born than US-born individuals, but HPV-related (e.g., cervical) cancer risks are disproportionately higher among immigrant populations. Although timely vaccination can help reduce these risks, less is known about differences in the low HPV vaccination uptake among foreign-born groups, especially Black immigrants. The purpose of this study was to examine the differences in HPV vaccination initiation among US- and foreign-born Black men and women.MethodData from the 2013 –2017 National Health Interview Survey on Black adults, aged...
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
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Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: STD: Edited by Joseph A. Duncan Source Type: research
Kato Cervical cancer is the fourth most common cancer in women worldwide and is predominantly caused by infection with human papillomavirus (HPV). However, a small subset of cervical cancers tests negative for HPV, including true HPV-independent cancers and false-negative cases. True HPV-negative cancers appear to be more prevalent in certain pathological adenocarcinoma subtypes, such as gastric- and clear-cell-type adenocarcinomas. Moreover, HPV-negative cervical cancers have proven to be a biologically distinct tumor subset that follows a different pathogenetic pathway to HPV-associated cervical cancers. HPV-negativ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
CONCLUSIONS: These data provide a reliable reference for future epidemiological studies, including those concerning the effectiveness of HPV vaccination.PMID:34913243 | DOI:10.1111/1471-0528.17058
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Source Type: research
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Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
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