Stages of Lyme Arthritis

Conclusions and Future Research Lyme arthritis provides unique insights into the complex interplay between microbes and host immunity. The progression from localized erythema migrans to early disseminated disease and late Lyme arthritis allows insight into arthritis initiation, and the study of postinfectious Lyme arthritis allows further insight into mechanisms of arthritis persistence.
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Reviews Source Type: research

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Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells and molecular pathways that govern TLT formation are poorly defined. Here, we identified TNF superfamily CD153/CD30 signaling between 2 unique age-dependent lymphocyte subpopulations, CD153+PD-1+CD4+ senescence-associated T (SAT) cells and CD30+T-bet+ age-associated B cells (ABCs), as a driver for TLT expansion. SAT cells, which produced ABC-inducing factors IL-21 and IFN-γ, and ABCs progressively accumulated within TLTs in aged kidneys after injury. Notably, in kidney injury models, CD153 or...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Suppressing inflammation has been the primary focus of therapies in autoimmune rheumatic diseases (AIRDs), including rheumatoid arthritis and systemic lupus erythematosus. However, conventional therapies with low target specificity can have effects on cell metabolism that are less predictable. A key example is lipid metabolism; current therapies can improve or exacerbate dyslipidemia. Many conventional drugs also require in vivo metabolism for their conversion into therapeutically beneficial products; however, drug metabolism often involves the additional formation of toxic by-products, and rates of drug metabolism can be ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Memory B cells (MBCs) can provide a recall response able to supplement waning antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses. We studied a cohort of elderly care home residents and younger staff (median age of 87 years and 56 years, respectively), who had survived COVID-19 outbreaks with only mild or asymptomatic infection. The cohort was selected because of its high proportion of individuals who had lost neutralizing antibodies (nAbs), thus allowing us to specifically investigate the reserve immunity from SARS-CoV-2–specific MBCs in this setting. Class-switched spike and...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
A pet shop outbreak in "zero Covid" Hong Kong will result in the euthanasia of 2,000 small mammals.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
In this study we are interested to investigate the subjective well-being, which is expressed by mental health and components of general happiness, of the givers rather than of receivers. We apply a difference-in-differences framework to investigate the impact of altruism on the givers ’ SWB in the UK. Altruism is denoted by transfers made to adult children, parents, siblings, and friends. Using the DiD estimator and the estimated coefficient of the household income we calculate the implicit willingness-to-pay (WTP) for altruism. We perform various regressions by gender and raci al-ethnic background using data from th...
Source: Applied Research in Quality of Life - Category: International Medicine & Public Health Source Type: research
This study aimed to elucidate the underlying pathophysiology of chilblain-like lesions which some patients developed during the COVID-19 pandemic.The British Journal of Dermatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
Since early 2020, the world has been living through coronavirus disease 2019 (COVID-19). Westchester County, New York, was one of the hardest and earliest hit places in the United States. Working within a community emergency department amid the rise of a highly infectious disease such as COVID-19 presented many challenges, including appropriate isolation, adequate testing, personnel shortages, supply shortfalls, facility changes, and resource allocation. Here we discuss our process in navigating these complexities, including the practice changes implemented within our institution to counter these unprecedented issues. Thes...
Source: Western Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
Cell Mol Life Sci. 2022 Jan 17;79(2):75. doi: 10.1007/s00018-021-04119-8.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new member of the Betacoronaviridae family, responsible for the recent pandemic outbreak of COVID-19. To start exploring the molecular events that follow host cell infection, we queried VirusCircBase and identified a circular RNA (circRNA) predicted to be synthesized by SARS-CoV-2, circ_3205, which we used to probe: (i) a training cohort comprised of two pools of cells from three nasopharyngeal swabs of SARS-CoV-2 infected (positive) or uninfected (negative, UCs) individuals; (i...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Source Type: research
Best Pract Res Clin Rheumatol. 2021 Dec 31:101736. doi: 10.1016/j.berh.2021.101736. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) can have various infectious mimics. As immunosuppressive agents used in treatment can aggravate the underlying infections, correct diagnosis of RA and ruling out infections is important. Numerous viral infections (Parvovirus B19, Hepatitis B, Hepatitis C, Chikungunya and other alphaviruses, human immunodeficiency virus (HIV) and various other viruses), mycobacterial infections (Poncet's disease, tubercular septic arthritis, and leprosy), bacterial arthritis, brucellosis and Lyme diseas...
Source: Cell Research - Category: Cytology Authors: Source Type: research
For most of us, springtime marks the return of life to a dreary landscape, bringing birdsong, trees in bud, and daffodils in bloom. But if you work for the Centers for Disease Control and Prevention (CDC), the coming of spring means the return of nasty diseases spread by ticks and mosquitoes. The killjoys at CDC celebrated the end of winter with a bummer of a paper showing that infections spread by ticks doubled in the United States from 2004 to 2016. (Tick populations have exploded in recent decades, perhaps due to climate change and loss of biodiversity.) Lyme disease The most common infection spread by ticks in the US i...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Source Type: blogs
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