Influence of cytotoxic T lymphocyte antigen 4 genetic variants on acute rejection in kidney transplant patients: precision medicine perspective

ConclusionsThe results of the presented study suggest that rs231775 and rs5742909 ofCTLA4 genetic variants are not linked to acute rejection who underwent kidney transplantation. So, these variants cannot be considered as risk factors of acute allograft rejection in a group of Iranian renal transplantation recipients. However, the transplantation precision medicine may be an important area for the improvement of patients outcome as the precision medicine has already entered clinical practice in kidney transplantation.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research

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Conclusion: Surges of systemic inflammation due to infection were paralleled by instability of coronary plaques as documented by repeat coronary angiograms.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusions. Chronic NoV infection is associated with reduced allograft function. Administration of IVIg to patients with chronic NoV infection seems beneficial in achieving freedom from clinical symptoms, despite limited effects on shedding of virus.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
COVID 19 (SARS-COV-2) disease expression remains uncertain. Immunocompromised individuals may be at particular risk of increased mortality. Lung transplant recipients provide a unique phenotype because the allograft is a preferred host location for the SARS-COV-2.We conducted a single centre review of all lung transplant recipients SARS-COV-2 PCR positive between 17th March and June 2020. 7 of a total of 266 lung transplant recipients were SARS-COV-2 positive. 4 cases had a descriptive analysis of the immune microenvironment.There was no association between COVID 19 disease severity and time from transplant. The most preva...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
Modern Pathology, Published online: 28 September 2021; doi:10.1038/s41379-021-00927-2Long-standing donor diabetes and pathologic findings are associated with shorter allograft survival in recipients of kidney transplants from diabetic donors
Source: Modern Pathology - Category: Pathology Authors: Source Type: research
Exp Clin Transplant. 2021 Sep;19(9):899-909. doi: 10.6002/ect.2021.0188.ABSTRACTOBJECTIVES: Data are so far limited on outcomes of kidney transplant recipients with COVID-19 seen at public sector hospitals in developing countries with limited resources.MATERIALS AND METHODS: We retrospectively investigated a cohort of 157 kidney transplant recipients (75% living and 25% deceased donors) seen at a public sector transplant hospital in India from March to December 2020 who had reverse-transcriptase polymerase chain reaction tests that confirmed COVID-19. Demographic data, immunosuppression regimens, clinical profiles, treatme...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Source Type: research
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