GSE163838 mRNA vaccine efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after the challenge

Contributors : Michelle Meyer ; Yuan Wang ; Darin Edwards ; Gregory R Smith ; Aliza B Rubenstein ; Palaniappan Ramanathan ; Chad E Mire ; Colette Pietzsch ; Xi Chen ; Yongchao Ge ; Wan S Cheng ; Carole Henry ; Angela Woods ; Ling Z Ma ; Guillaume Stewart-Jones ; Kevin W Bock ; Mahnaz Minai ; Bianca M Nagata ; Sivakumar Periasamy ; Pei Y Shi ; Barney S Graham ; Ian N Moore ; Irene Ramos ; Olga G Troyanskaya ; Elena Zaslavsky ; Andrea Carfi ; Stuart C Sealfon ; Alexander BukreyevSeries Type : Expression profiling by high throughput sequencingOrganism : Mesocricetus auratusmRNA-1273, an mRNA-based vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is efficacious in mouse and non-human primate models of mild COVID-19. Hamsters exhibit more severe clinical disease from SARS-CoV-2, making it an important model to evaluate vaccine efficacy. Here we show that mock-vaccine treated hamsters infected with SARS-CoV-2 show weight loss and pulmonary infection with pathological changes and increased activated interstitial macrophages and other immune cell types. Prime-boost administration of mRNA-1273 elicited dose-independent robust binding and neutralizing antibodies, ameliorated weight loss and suppressed virus replication in the upper and lower airways. Vaccination largely prevented pulmonary pathological changes, antiviral immune cell activation and changes in cell type composition although increases in some immune cell types and activation of reg...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mesocricetus auratus Source Type: research