“ Engineered extracellular matrix models to study tumor heterogeneity ”

The development, progression, and therapy response of cancer is determined by the evolution of intratumor heterogeneity. How extracellular matrix (ECM) remodeling regulates the phenotypic diversity of tumor and stromal cells and which consequences these changes have on malignancy, however, remains poorly understood. Increasing knowledge of these connections is critical as aberrant ECM remodeling often precedes tumor development (e.g. during obesity), regulates many different hallmarks of cancer including proliferation, metabolism, and angiogenesis, and can be used to diagnose and treat cancer more effectively. Studying the functional links between ECM remodeling and cancer requires model systems that allow isolating the physicochemical heterogeneity of malignancy-associated ECM for mechanistic studies. In this talk, I will review the compositional, microarchitectural, and mechanical hallmarks of pro-tumorigenic ECM and highlight biomaterials and engineering approaches to recapitulate these properties for in vitro and in vivo studies of cancer. Subsequently, I will describe how such engineered platforms may be explored to define the functional links between cancer-associated ECM remodeling, tumor invasion, and discuss potential implications for metastasis.For more information go tohttps://oir.nih.gov/sigs/biomedical-engineering-scientific-interest-groupAir date: 12/9/2021 1:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video

Related Links:

Conditions:   Barrett Esophagus;   GERD;   Obesity;   Esophageal Cancer Intervention:   Diagnostic Test: Esocheck/Esoguard Sponsors:   Cleveland VA Medical Research and Education Foundation;   United States Department of Defense Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: International Journal of Womens Health - Category: OBGYN Tags: International Journal of Women's Health Source Type: research
Nat Rev Clin Oncol. 2022 Jan 26. doi: 10.1038/s41571-022-00600-w. Online ahead of print.ABSTRACTThe development of immune-checkpoint inhibitors (ICIs) has heralded a new era in cancer treatment, enabling the possibility of long-term survival in patients with metastatic disease, and providing new therapeutic indications in earlier-stage settings. As such, characterizing the long-term implications of receiving ICIs has grown in importance. An abundance of evidence exists describing the acute clinical toxicities of these agents, although chronic effects have not been as well catalogued. Nonetheless, emerging evidence indicate...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Front Med (Lausanne). 2022 Jan 10;8:800426. doi: 10.3389/fmed.2021.800426. eCollection 2021.ABSTRACTBackground: Understanding the spatiotemporal trends of colorectal cancer (CRC) deaths caused by low physical activity (LPA) and high body mass index (BMI) is essential for the prevention and control of CRC. We assessed patterns of LPA and high BMI-induced CRC deaths from 1990 to 2019 at global, regional, and national levels. Methods: Data on CRC deaths due to LPA and high BMI was downloaded from the Global Burden of Disease 2019 Study. We calculated estimated annual percentage change (EAPC) to quantify spatiotemporal trends ...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
ConclusionOne in six individuals with HF have no recorded RFs or RFs without trials. We provide a systematic map of primary preventive opportunities across a wide range of RFs for HF, demonstrating a high burden of co-occurrence and the need for trials tackling multiple RFs.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
cute;nez-Moleón Obesity is associated with negative prostate cancer outcomes (e.g., specific mortality, all-cause mortality, biochemical recurrence, etc.), according to the current scientific literature. Nevertheless, recommendations on weight loss and healthy lifestyles are poorly covered by clinicians. We aimed at identifying these recommendations from clinical practice guidelines (CPGs) for prostate cancer. We systematically searched MEDLINE, EMBASE, Web of Science, Scopus, guideline databases and online sources for CPGs updated from January 2015 to August 2021. The searches were independently conducted by tw...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
This study assesses the relationship between PA level and cancer status considering the full activity spectrum within a large and representative Chinese population.MethodsData were derived from the Chinese Health and Retirement Longitudinal Study (using four-stage stratified probability-proportional-to-size sampling), including 416 cancer survivors and 14,574 individuals without cancer from 28 provinces in China. Cancer status and sites were self-reported, and PA, other health behaviors (e.g., smoking, drinking) and comorbidities (e.g., hypertension, diabetes) were assessed by a questionnaire. The total PA score was calcul...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
BackgroundThere was no consensus for management of asymptomatic endometrial polyps (EPs) up to date.ObjectiveThe aim of present study was to determine the risk factors of malignant lesions in EPs diagnosed by ultrasound and establish a noninvasive predictor to decrease unnecessary hysteroscopy for EPs.Study DesignWe reviewed the records of all consecutive patients who underwent hysteroscopy for EPs in the Women’s Hospital School of Medicine Zhejiang University between January 1, 2001 and December 31, 2018. The patients with histological diagnoses of atypical hyperplasia or cancer were defined as malignancy, while the...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThe risk of perioperative thrombosis in UC patients was considered similar to that in CRC, so active thromboprophylaxis should be administered to UC patients while paying attention to bleeding.Trial registrationThis study was registered with the Japanese Clinical Trials Registry as UMIN000042004 (http://www.umin.ac.jp/ctr/index.htm).
Source: Surgery Today - Category: Surgery Source Type: research
Curr Drug Targets. 2022 Jan 17. doi: 10.2174/1389450123666220117105531. Online ahead of print.ABSTRACTRecent studies have shed light on the role of epigenetic marks in certain diseases like cancer, type II diabetes mellitus (T2DM), obesity, and cardiovascular dysfunction, to name a few. Epigenetic marks like DNA methylation and histone acetylation are randomly altered in the disease state. It has been seen that methylation of DNA and histones can result in down-regulation of gene expression, whereas histone acetylation, ubiquitination, and phosphorylation are linked to enhanced expression of genes. How can we precisely tar...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Source Type: research
More News: Biomedical Engineering | Cancer | Cancer & Oncology | Eating Disorders & Weight Management | General Medicine | Obesity | Study