A rare case of intestinal lymphangiectasia induced by pazopanib

AbstractA 62-year-old man underwent left radical nephrectomy for left renal cell carcinoma at our hospital in 1999. At the age of 79  years, he was diagnosed with intra-abdominal disseminations, lung metastases, pancreas metastases, and bilateral femoral muscle metastases during a routine follow-up computed tomography scan. The patient began treatment with pazopanib. Four years later, at the age of 83 years, he developed fever, abdominal pain, and general malaise. Blood samples showed liver dysfunction, hypoalbuminemia, and anemia. Contrast-enhanced computed tomography showed thickening of the small bowel wall with marked edema of the submucosa from the third part of the duodenum to the jejunum, suggesting intestinal lymp hangiectasia. The diagnosis of intestinal lymphangiectasia was confirmed by small bowel endoscopy and histological examination. The patient’s general condition improved after discontinuation of pazopanib without the need for any active therapeutic interventions. The possibility of intestinal lymph angiectasia should be considered in patients with hypoalbuminemia and general malaise during treatment with multikinase inhibitors.
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research