Radiofrequency ablation vs radiation therapy vs transarterial chemoembolization vs yttrium 90 for local treatment of liver cancer - a systematic review and network Meta-Analysis of survival data

CONCLUSION: All modalities assessed resulted in similar OS, which explains the current heterogenous practice patterns. This conclusion may assist in decision making based on administrative and patient costs, and implementation of these modalities. Other factors such as toxicity rate specific to individual patients could not be assessed using network meta-analysis and may also play a role in selection of modality. Further studies, ideally using PSM cohort analyses or RCT study design, reporting on OS, PFS, local control, complete response and toxicity are needed prior to drawing definitive conclusions.PMID:34846988 | DOI:10.1080/0284186X.2021.2009563
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Source Type: research

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Radiotherapy (RT) is one of the main treatments for patients with unresectable hepatocellular carcinoma (HCC). Emerging evidence indicates that the cGAS-STING pathway is crucial in RT-induced antitumor immune responses. Here, we discovered that activation of the cancer cell-intrinsic cGAS-STING pathway mediated immune-cloaking after RT-induced DNA damage.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Biology Contribution Source Type: research
We present the update of the recommendations of the French society of oncological radiotherapy on hepatic tumours. Recent technological progress led to develop the concept of focused liver radiation therapy. We must distinguish primary and secondary tumours, as the indications are restricted and must be discussed as an alternative to surgical or medical treatments. The tumour volume, its liver location close to the organs at risk determine the irradiation technique (repositioning method, total dose delivered, dose fractionation regimens). Tumour (and liver) breathing related motions should be taken into account. Strict dos...
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: Four fractions of C-ion RT for HCC did not yield serious adverse events and showed promising LC, thus making it a safe and effective modality for this type of malignancy.Liver Cancer
Source: Liver Cancer - Category: Cancer & Oncology Source Type: research
In conclusion, surgery for cervical radioiodine refractory FTC relapse is often performed in metastatic setting. With and without EBRT, cure is rare, although metastases can appear radioiodine avid. Early biological marker and systemic treatments for these patients are still needed.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
CONCLUSION: All modalities assessed resulted in similar OS, which explains the current heterogenous practice patterns. This conclusion may assist in decision making based on administrative and patient costs, and implementation of these modalities. Other factors such as toxicity rate specific to individual patients could not be assessed using network meta-analysis and may also play a role in selection of modality. Further studies, ideally using PSM cohort analyses or RCT study design, reporting on OS, PFS, local control, complete response and toxicity are needed prior to drawing definitive conclusions.PMID:34846988 | DOI:10...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Source Type: research
milović-Radjenović Microwave ablation at 2.45 GHz is gaining popularity as an alternative therapy to hepatic resection with a higher overall survival rate than external beam radiation therapy and proton beam therapy. It also offers better long-term recurrence-free overall survival when compared with radiofrequency ablation. To improve the design and optimization of microwave ablation procedures, numerical models can provide crucial information. A three-dimensional model of the antenna and targeted tissue without homogeneity assumptions are the most realistic representation of the physical problem. Due to complexity a...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractPrimary ObjectiveRecently, selective internal radiation therapy using yttrium-90 (Y90) glass microspheres (TheraSphere ™) was approved for reimbursement by health authorities in France. The PROACTIF study aims to gather data on effectiveness, patient quality of life, and safety with use of Y90 glass microspheres in real-world clinical settings in France.Inclusion CriteriaPatient with a diagnosis of hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCC), and/or metastatic colorectal cancer (mCRC) who was treated with a dose of Y90 glass microspheres that has been reimbursed in France and who do ...
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
ers Nahid Mostafavi Jan Ijzermans R. Bart Takkenberg Selective internal radiation therapy (SIRT) is used as a treatment for hepatocellular carcinoma (HCC). The aim of this study was to assess long-term liver-related complications of SIRT in patients who had not developed radioembolization-induced liver disease (REILD). The primary outcome was the percentage of patients without REILD that developed Child-Pugh (CP) ≥ B7 liver decompensation after SIRT. The secondary outcomes were overall survival (OS) and tumor response. These data were compared with a matched cohort of patients treated with sorafenib. Eighty-fi...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e134-e135. doi: 10.1016/j.ijrobp.2021.07.571.ABSTRACTPURPOSE/OBJECTIVE(S): To develop improved NTCP models of liver function using pre-/during-treatment DCE-MRI for adaptation of radiation therapy (RT) in hepatocellular cancer (HCC) patients who receive SBRT. The liver function map based on Gadoxetate uptake rate (k1) is compared to portal venous perfusion for HCC NTCP models.MATERIALS/METHODS: 194 HCC patients who received SBRT were evaluated. Subcohorts of patients (n = 23, each) with either portal venous perfusion or Gadoxetate uptake rate k1 liver function maps calculate...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Source Type: research
ConclusionAlthough the existing evidence demonstrates a dose-response relationship in SIRT for both primary liver tumours and liver metastases, many pieces of the puzzle are still missing, hampering the definition of standardized dose thresholds. Nonetheless, most current evidence points towards a target mean dose of 100 –250 Gy for HCC and 40–60 Gy for CRC. The field would greatly benefit from a reporting standard and prospective studies designed to elucidate the dose-response relation in different tumour types.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
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