Is There Still a Role for Sulfonylureas in Type 2 Diabetes?

Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research

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This report describes the percentage of adults with diabetes by disability status and age group.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Adult Health Disabilities Disabilities and Health MMWR Morbidity & Mortality Weekly Report Diabetes Type 2 Diabetes People with Disabilities Source Type: news
In this study, we investigated the mechanism by which C/EBPα regulates the lipase family member N (Lipn) gene in the mouse liver. Mouse Lipn consists of non-coding exon 1 and the translation start site located in exon 2. Lipn expression in the fatty liver of ob/ob mice was significantly higher than that in OB/OB mice and was significantly repressed by liver-specific C/EBPα deficiency. Lipn expression in ob/ob mice was detected in the liver, epididymal WAT (eWAT), subcutaneous WAT (sWAT), brown adipose tissue (BAT), and skeletal muscle, but not in the kidney, brain, and heart. Lipn expression in the liver, eWAT,...
Source: Endocrine Journal - Category: Endocrinology Authors: Source Type: research
In conclusion, all long-acting insulins were a powerful tool for treatment of type 2 diabetes, and patients with short duration of diabetes and/or no usage of insulin secretagogues resulted in favorable outcomes in terms of insulin withdrawal within a year in an outpatient setting. In addition, insulin degludec/insulin aspart was found to possibly be a better choice for treatment when it was compared with glargine U100 among the four types of insulin.PMID:35082188 | DOI:10.1507/endocrj.EJ21-0647
Source: Endocrine Journal - Category: Endocrinology Authors: Source Type: research
CONCLUSION: The PLR and NLR may be related to carotid inflammation in patients and positively correlated with carotid plaque.PMID:35085053 | DOI:10.1177/17085381211052362
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Front Endocrinol (Lausanne). 2022 Jan 10;12:775677. doi: 10.3389/fendo.2021.775677. eCollection 2021.ABSTRACTHigh plasma triglyceride (TG) levels and chronic inflammation are important factors related to metabolic-associated fatty liver disease in patients at cardiovascular risk. Using nuclear magnetic resonance (1H-NMR), we aimed to study the triglyceride-rich lipoprotein (TRL) and acute-phase glycoprotein profiles of a cohort of patients with metabolic disease and their relationship with fatty liver. Plasma samples of 280 patients (type 2 diabetes, 81.1%; obesity, 63.3%; and metabolic syndrome, 91.8%) from the University...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Conclusion. Preconditioning of AD-MSCs with OXA can significantly increase their potential to reduce the insulin resistance in the rat model of T2DM.PMID:35083338 | PMC:PMC8786498 | DOI:10.1155/2022/9832212
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSIONS: The contents of ceramides and sphingosine in lipoproteins and lipoprotein-depleted fractions were differently modulated in diabetes and associated with cardiovascular diseases and diabetic nephropathy. The carrier might be an important factor for the biological properties and clinical significance of these sphingolipids.PMID:35082227 | DOI:10.5551/jat.63249
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Authors: Source Type: research
Conclusion, we show that liraglutide may have a therapeutic effect on rats with T2DM and MAFLD by reducing endoplasmic reticulum stress in the liver and increasing the expression of Insig-1.PMID:35081898 | DOI:10.2174/1871530322666220126151141
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Source Type: research
Conclusions: Silent heart ischemia is more common in type 2 than type 1 diabetes. Predisposing factors include older age, coexistence of carotid atherosclerosis, lower left ventricular ejection fraction, and smoking in patients with type 1 diabetes. Concomitant microvascular complications are not a risk factor.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
This study aimed to explore the effect of fear of hypoglycaemia (FOH) on self-management and its specific action path in patients with type 2 diabetes mellitus (T2DM) to provide a basis for developing targeted nursing interventions.DesignA cross-sectional study.MethodsFrom June to October 2019, we recruited 258 patients with T2DM from the endocrinology department of three hospitals to complete questionnaires, including the Hypoglycaemia Fear Survey-II, Diabetes Distress Scale, Self-Stigma Scale, Social Support Rating Scale and Summary of Diabetes Self-Care Activities, in Jiangsu Province, China. Pearson ’s correlatio...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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