Genes, Vol. 12, Pages 1934: HLA-DQA1*05 Associates with Extensive Ulcerative Colitis at Diagnosis: An Observational Study in Children

Genes, Vol. 12, Pages 1934: HLA-DQA1*05 Associates with Extensive Ulcerative Colitis at Diagnosis: An Observational Study in Children Genes doi: 10.3390/genes12121934 Authors: Jan Krzysztof Nowak Aleksandra Glapa-Nowak Aleksandra Banaszkiewicz Barbara Iwańczak Jarosław Kwiecień Anna Szaflarska-Popławska Urszula Grzybowska-Chlebowczyk Marcin Osiecki Jarosław Kierkuś Magdalena Hołubiec Justyna Chanaj-Kaczmarek Andrzej Radzikowski Jarosław Walkowiak The human leukocyte antigen (HLA) allele group HLA-DQA1*05 predisposes to ulcerative colitis (UC) and is associated with the development of antibodies against infliximab in patients with inflammatory bowel disease (IBD). Therefore, we hypothesized that the presence of HLA-DQA1*05 correlates with characteristics of pediatric IBD. Within a multi-center cohort in Poland, the phenotype at diagnosis and worst flare was established and HLA-DQA1*05 status was assessed enabling genotype-phenotype analyses. HLA-DQA1*05 was present in 221 (55.1%) out of 401 children with IBD (UC n = 188, Crohn’s disease n = 213). In UC, the presence of HLA-DQA1*05 was moderately associated with a large extent of colonic inflammation at diagnosis (E4 55% more frequent in HLA-DQA1*05-positive patients, p = 0.012). PUCAI at diagnosis (p = 0.078) and the time from UC diagnosis to the first administration of biologic treatment (p = 0.054) did not differ depending on HLA-DQA1*05 status. The number of days of hospital...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research

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Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
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Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Authors: Source Type: research
Conditions:   Ulcerative Colitis Chronic;   Crohn Disease Colon Intervention:   Other: No intervention Sponsors:   Kazakhstan Scientific Society for Study of intestine diseases;   FERRING Kazakhstan Recruiting
Source: - Category: Research Source Type: clinical trials
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