Is Grade Group 1 (Gleason score 3 + 3 = 6) adenocarcinoma of the prostate really cancer?

Purpose of review Whether Grade Group 1 (GG1) prostate cancer is really cancer remains controversial. Recent findings Favoring renaming GG1 with a noncancerous diagnosis are: fear of the term cancer, which will lead to overtreatment of GG1; and indolence of GG1. Favor designating GG1 as cancer are: morphologically, GG1 may be indistinguishable from GG2 to GG5 and GG1 is invasive (lacks basal cells), can show perineural invasion and extraprostatic extension; molecularly, GG1 has many of the hallmarks of prostate cancer; calling GG1 noncancer would lead to inconsistencies and confusion in reporting; sampling error with GG1 on biopsy can miss higher grade cancer; removing the label of cancer in men with GG1 on biopsy may make it challenging to insure follow-up during active surveillance; the prognosis of treated GG1 may not be the same if GG1 called noncancer and not treated; with Grade Group terminology, GG1 is more intuitive to patients as lowest grade cancer; and patients are increasingly adopting active surveillance, recognizing that not all prostate cancers are the same and GG1 can be followed carefully and safely on active surveillance. Summary There is strong support for retaining the carcinoma designation for GG1.
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: PROSTATE CANCER: Edited by Matthew Cooperberg and Ashutosh K. Tewari Source Type: research

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Conditions:   Castration-Resistant Prostate Carcinoma;   Metastatic Prostate Adenocarcinoma;   Stage IV Prostate Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8 Interventions:   Biological: Atezolizumab;   Drug: Cabozantinib S-malate Sponsors:   University of Utah;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study aims to evaluate PTEN loss and PD-L1 expression by immunohistochemistry in different histological patterns of PCa.METHODS: The current study included consecutive 98 radical prostatectomy specimens with 151 foci with different Gleason Grade (GG) patterns.RESULTS: The highest frequency of PTEN loss was observed in GG4 cribriform and glomeruloid patterns (59.3%, p
Source: Cell Research - Category: Cytology Authors: Source Type: research
Clin Genitourin Cancer. 2021 Nov 5:S1558-7673(21)00201-9. doi: 10.1016/j.clgc.2021.10.010. Online ahead of print.ABSTRACTOBJECTIVE: To test 1) contemporary pelvic lymph node dissection (PLND) trends at radical cystectomy (RC) in variant histology bladder cancer (VHBC) patients and urothelial carcinoma of the urinary bladder (UCUB), as well as 2) to test the effect of PLND extent on cancer specific mortality (CSM) after RC.METHODS: Within the Surveillance, Epidemiology and End Results Registry (SEER, 2004-2016), we identified non-metastatic stage T1-2 or T3-4 VHBC and UCUB patients, who underwent RC. CSM and lymph node inva...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: Palliative 177Lu-PSMA therapy for salivary gland cancer may lead to rapid relief of tumour-associated discomfort and may even induce disease stabilization. It is safe, relatively well tolerated and can be considered when regular treatment options fail.PMID:34905121 | DOI:10.1186/s13550-021-00866-8
Source: Cell Research - Category: Cytology Authors: Source Type: research
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