Orto-hydroxy bioactive schiff base compounds: Design, comprehensive characterization, photophysical properties and elucidation of antimicrobial and mutagenic potentials

Bioorg Chem. 2021 Nov 22:105507. doi: 10.1016/j.bioorg.2021.105507. Online ahead of print.ABSTRACTPreparation and comprehensive characterization of three Schiff base ligands; with trimethoxy substitution (1E,1'E)-N,N'-(naphthalene-1,5-diyl)bis(1-(3,4,5-trimethoxyphenyl)methanimine, 1, with ortho-hydroxy substitution 6,6'-((1E,1'E)-(naphthalene-1,5-diylbis(azaneylylidene))bis(methaneylylidene))bis(2-methoxyphenol), 2 and 3,4-bis(((E)-2-hydroxy-3-methoxy benzylidene)amino)benzoicacid, 3 and their Ni(II), Cu(II), Co(II), Zn(II), Fe(II), Mn(II) complexes have been reported. Their spectral properties were studied in solution and solid-state by a combination of different analytical techniques; FT-IR spectroscopy, 1H NMR and 13C NMR spectroscopy, elemental analysis and thermal analysis. Diamagnetic and paramagnetic natures of the complexes were also determined by magnetic susceptibility measurements in solid-state. Promising photophysical properties were observed as; Amax. were recorded at 226 nm for 2; at 795 nm for 2-Ni, at 782 nm for 2-Cu, at 784 nm for 2-Co, at 702 nm for 2-Zn, at 784 nm for 2-Fe, at 702 nm for 2-Mn and at 289 nm for 3, at 786 nm for 3-Ni, at 797 nm for 3-Cu, at 746 nm for 3-Co, at 794 nm for 3-Zn, at 699 nm for 3-Fe, at 781 nm for 3-Mn ; and Imax were also recorded at; 380, 490, 725 nm for 2 and 2-Metal; 375 nm, 510 nm, 725 nm for 3 and 3-Metal when excitated at 220 nm. Antibacterial activities against different microorganisms; Escherichia coli ATCC 25922, Pseu...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research

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Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Environ Res. 2022 Jan 18:112723. doi: 10.1016/j.envres.2022.112723. Online ahead of print.ABSTRACTDiclofenac is an anti-inflammatory drug and has been frequently detected from the wastewater. In the present study, factors affecting diclofenac adsorption on sewage sludge was evaluated. At 1 mg/L initial diclofenac concentration, more than 80% diclofenac removal was achieved. Adsorption increased at higher concentration (100 mg/L concentration) and more than 99% diclofenac was adsorbed from the wastewater. Significant removal of diclofenac was observed after 5 min contact time. The adsorption efficacy was more than 98% after...
Source: Environmental Research - Category: Environmental Health Authors: Source Type: research
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Source: Environmental Research - Category: Environmental Health Authors: Source Type: research
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Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research
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Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research
AbstractMethicillin resistantStaphylococcus aureus is considered multidrug resistant bacterium due to developing biofilm formation associated with antimicrobial resistance mechanisms. Therefore, inhibition of biofilm formation is an alternative therapeutic action to control MRSA infections. The present study revealed the non-antibacterial biofilm inhibitory potential of hesperidin against ATCC strain and clinical isolates ofS. aureus. Hesperidin is a flavanone glycoside commonly found in citrus fruit. Hesperidin has been shown to exhibits numerous pharmacological activities. The present study aimed to evaluate the antibiof...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Authors: Ogidi OC, Oyetayo VO, Akinyele BJ Abstract In recent time, there is a major concern about antibiotic resistance displayed by some pathogenic microorganisms and this had involved a continuous search for natural antimicrobial products. The phytochemistry as well as antimicrobial activity of extracts obtained from Lenzites quercina was investigated. The extracts and purified fractions were, respectively, tested against indicator organisms using agar well diffusion and disc diffusion methods. The quantity of phytochemicals found in the extracts of L. quercina ranged from 14.4 to 20.7 mg/g for alkaloids,...
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
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