Pulmonary Hypertension in Extremely Preterm Infants

Conditions:   Bronchopulmonary Dysplasia;   Pulmonary Hypertension;   Premature Birth Interventions:   Diagnostic Test: Echocardiography;   Diagnostic Test: NT-proBNP Sponsors:   Universitair Ziekenhuis Brussel;   AZ Sint-Jan AV;   Universitaire Ziekenhuizen Leuven;   GZA Ziekenhuizen Campus Sint-Augustinus;   Ziekenhuis Netwerk Antwerpen (ZNA);   Ziekenhuis Oost-Limburg;   University Hospital, Ghent Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Acute respiratory distress syndrome (ARDS) is characterized by protein-rich alveolar edema, reduced lung compliance and severe hypoxemia. Despite some evidence of improvements in mortality over recent decades, ARDS remains a major public health problem with 30% 28-day mortality in recent cohorts. Pulmonary vascular dysfunction is one of the pivot points of the pathophysiology of ARDS, resulting in a certain degree of pulmonary hypertension, higher levels of which are associated with morbidity and mortality. Pulmonary hypertension develops as a result of endothelial dysfunction, pulmonary vascular occlusion, increased vascu...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Intern Med. 2022 Jan 13. doi: 10.2169/internalmedicine.8667-21. Online ahead of print.ABSTRACTUnilateral absence of the pulmonary artery (UAPA) with or without other anomalies in the heart is a rare congenital malformation. A 55-year-old Filipino woman without a remarkable medical history was admitted to our hospital for hemoptysis. Contrast-enhanced chest computed tomography revealed the absence of the left pulmonary artery. Echocardiography and right heart catheterization showed no cardiac malformations or pulmonary hypertension. We diagnosed her with isolated left-sided UAPA and performed transarterial embolization of t...
Source: Internal Medicine - Category: Internal Medicine Authors: Source Type: research
Conclusion Dasatinib-induced PAH does not occur time- or dose-dependently. When administering dasatinib, cardiovascular diagnostic modalities should be routinely checked, and PAH occurrence should be promptly detected.PMID:35022343 | DOI:10.2169/internalmedicine.8392-21
Source: Internal Medicine - Category: Internal Medicine Authors: Source Type: research
Intern Med. 2022 Jan 13. doi: 10.2169/internalmedicine.8667-21. Online ahead of print.ABSTRACTUnilateral absence of the pulmonary artery (UAPA) with or without other anomalies in the heart is a rare congenital malformation. A 55-year-old Filipino woman without a remarkable medical history was admitted to our hospital for hemoptysis. Contrast-enhanced chest computed tomography revealed the absence of the left pulmonary artery. Echocardiography and right heart catheterization showed no cardiac malformations or pulmonary hypertension. We diagnosed her with isolated left-sided UAPA and performed transarterial embolization of t...
Source: Internal Medicine - Category: Internal Medicine Authors: Source Type: research
Conclusion Dasatinib-induced PAH does not occur time- or dose-dependently. When administering dasatinib, cardiovascular diagnostic modalities should be routinely checked, and PAH occurrence should be promptly detected.PMID:35022343 | DOI:10.2169/internalmedicine.8392-21
Source: Internal Medicine - Category: Internal Medicine Authors: Source Type: research
Introduction
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
Am J Respir Crit Care Med. 2022 Jan 12. doi: 10.1164/rccm.202104-1021OC. Online ahead of print.ABSTRACTRATIONALE: Extremely preterm infants develop bronchopulmonary dysplasia (BPD), a chronic lung injury that lacks effective treatment. Thrombospondin-1 is an anti-angiogenic protein that activates TGF-β1, a cytokine strongly linked to both experimental and human BPD.OBJECTIVES: 1) To examine effects of inhibiting thrombospondin-1-mediated TGF-β1 activation (LSKL) in neonatal rats with bleomycin-induced lung injury, 2) To examine effects of a thrombospondin-1-mimic (ABT-510) on lung morphology, and 3) To determine ...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research
CONCLUSIONS: These findings reveal an important role of the Notch4-ERK/JNK/P38 MAPK axis in hypoxic pulmonary remodeling and provide a potential therapeutic target for patients with HPH.PMID:35016680 | DOI:10.1186/s12931-022-01927-9
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research
Am J Respir Crit Care Med. 2022 Jan 12. doi: 10.1164/rccm.202104-1021OC. Online ahead of print.ABSTRACTRATIONALE: Extremely preterm infants develop bronchopulmonary dysplasia (BPD), a chronic lung injury that lacks effective treatment. Thrombospondin-1 is an anti-angiogenic protein that activates TGF-β1, a cytokine strongly linked to both experimental and human BPD.OBJECTIVES: 1) To examine effects of inhibiting thrombospondin-1-mediated TGF-β1 activation (LSKL) in neonatal rats with bleomycin-induced lung injury, 2) To examine effects of a thrombospondin-1-mimic (ABT-510) on lung morphology, and 3) To determine ...
Source: Am J Respir Crit Car... - Category: Intensive Care Authors: Source Type: research
CONCLUSIONS: These findings reveal an important role of the Notch4-ERK/JNK/P38 MAPK axis in hypoxic pulmonary remodeling and provide a potential therapeutic target for patients with HPH.PMID:35016680 | DOI:10.1186/s12931-022-01927-9
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research
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