IgA deposits in celiac disease. Their immunohistochemistry value in early diagnosis

Celiac disease (CD) is an immune-mediated enteropathy that arises in genetically susceptible individuals carrying the human leucocyte antigen (HLA) DQ2 or DQ8 haplotypes. It is characterized, histologically, by an increased number of intraepithelial T lymphocyte (> 25/100 epithelial cells) with or without crypt hyperplasia, and variable villous atrophy. These histological features are not pathognomonic of CD and integration with clinical, genetical and serological data is required to diagnose CD.   High serum levels of IgA anti-tissue transglutaminase type 2 (anti-TG2) and anti-endomysium (EMA) are typical features of untreated CD.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Commentary Source Type: research