Superiority of Concomitant Chemoradiation Over Sequential Chemoradiation in Inoperable, Locally Advanced Non–Small Cell Lung Cancer: Challenges in the Selection of Appropriate Chemotherapy

Treatment of inoperable, locally advanced non–small cell lung cancer (LA-NSCLC) is challenging and requires a multidisciplinary approach considering both local therapy and systemic therapy. Based on the results from several phase III studies and 2 meta-analyses, the use of concomitant chemoradiation therapy (ChRT) could significantly improve overall survival and is considered the standard of care in LA-NSCLC with good performance status. Currently, no evidence has shown a significant survival benefit of third-generation regimens applied in combination with ChRT compared with second-generation regimens.
Source: Seminars in Radiation Oncology - Category: Cancer & Oncology Authors: Source Type: research