Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C)

Behav Brain Res. 2021 Nov 25:113678. doi: 10.1016/j.bbr.2021.113678. Online ahead of print.ABSTRACTMaternal immune activation has been identified as a significant risk factor for schizophrenia. Using rodent models, past work has demonstrated various behavioral and brain impairments in offspring after immune-activating events. We applied 5mg/kg of poly(I:C) on gestation day 9 to pregnant mouse dams, whose offspring were then stressed during puberty. We show impairments in attentional set-shifting in a T-maze, and a decreased number of parvalbumin-positive interneurons in the hippocampus as a result of peripubertal stress specifically in females.PMID:34838932 | DOI:10.1016/j.bbr.2021.113678

Source: Behavioural Brain Research - November 28, 2021 Category: Neurology Authors: Kristyna Maleninska Martina Janikova Dominika Radostova Iveta Vojtechova Tomas Petrasek Denisa Kirdajova Miroslava Anderova Jan Svoboda Ales Stuchlik Source Type: research