Intraluminal Behavior of Various Transporter Substrates in the Rat Gastrointestinal Tract

CONCLUSION: This study revealed that the luminal concentration pattern of each drug differed considerably depending on the site because of the different absorption properties and luminal volumes. Although further investigation using a specific transporter inhibitor or transporter-knockout animals are necessary to clarify the actual contribution of each transporter to the drug absorption, this information will be valuable in evaluating transporter-mediated drug absorption in in vitro transport studies for ensuring optimal drug concentrations.PMID:34826378 | DOI:10.18433/jpps32314
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Source Type: research