Crohn disease: Identification, diagnosis, and clinical management

This article discusses early diagnosis, disease severity and classification, familial predisposition and genomics, and clinical management in the primary care setting.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: GASTROINTESTINAL DISORDERS: NCPD Connection Source Type: research

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Chronic pouchitis and Crohn's disease after Ileal pouch anal anastomosis (IPAA) for ulcerative colitis could be a larger issue than previously reported.
Source: American Journal of Surgery - Category: Surgery Authors: Source Type: research
Multiple studies have suggested that combination therapy with thiopurines and anti-TNFs is superior to monotherapy in Crohn's disease (CD) and ulcerative colitis (UC). The optimal dose of thiopurines in combination therapy remains unclear. Our aim was to determine the impact of thiopurine dosing in combination therapy on the formation of anti-TNF antibodies and clinical outcomes in inflammatory bowel disease (IBD).
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Uncontrolled Therapeutic Observations in Humans Using Biologic or Non-Biologic Agents Source Type: research
To assess the surgical outcome in Crohn ’s disease (CD) patients undergoing repeat ileocolic resection treated with biologic therapy prior to the surgical intervention.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Uncontrolled Therapeutic Observations in Humans Using Biologic or Non-Biologic Agents Source Type: research
Inflammatory bowel disease (IBD), consisting of both Crohn ’s Disease (CD) and ulcerative colitis (UC), affects nearly 80,000 children in the United States. African American patients have more perirectal phenotype which might indicate more severe disease activity however it is unclear why. There is no published data on transportation access and how it rel ates to pediatric IBD. The purpose of this study is to compare pediatric IBD patients with low access to care to those with more access to care and their severity of disease at diagnosis.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
This study involved an exploratory factor analysis (EFA) of the CCDS to better categorize IBD distress.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
IBD affects 3 million individuals in the US alone but the prevalence is expanding globally. The economic burden of IBD in the US is high, with estimates indicating the combined IBD population in the US is expected to incur a lifetime total cost of over $800 billion. Many current IBD treatments lose effectiveness over time and up to 80% of patients with Crohn ’s disease and 20% of patients with Ulcerative Colitis require at least one surgical intervention in their lifetime. Scientific evidence suggests diet, lifestyle factors, and mental health are emerging as key contributors to IBD’s pathogenesis but are often...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
Although current concepts of disease management of Crohn ’s Disease and ulcerative colitis (IBD) provide evidence of active engagement of patients, such a strategy is difficult to comply with unless multidisciplinary therapy is practiced.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
In this study, we used social media to examine patients’ experiences and concerns with CPF and assess its impact on their behavior and overall wellbeing.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
This study aimed to examine the temporal trends of anxiety and depression diagnoses in hospitalized CD patients in the United States.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
Although validated patient-reported outcome measurements (PRO) can categorize patients with inflammatory bowel disease (IBD) into remission or active disease, patients may have different definitions of remission. Patients may assume a new normal with altered bowel habits/abdominal pain after diagnosis or consider themselves to have active disease even though disease activity measures show remission. We aim to examine concordance between patient-defined remission and remission based on PRO-2 (ulcerative colitis; UC) or PRO-3 (Crohn ’s disease; CD), and associations with demographic and disease-related factors.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Practice Management/Quality of Care/Quality Assurance Source Type: research
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