Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin – A critical review

Publication date: March–April 2015 Source:Journal of Chemical Neuroanatomy, Volumes 64–65 Author(s): Rhiannon L. Schroeder , Kay L. Double , Jacobus P. Gerber Parkinson's disease is characterised pathologically by a relatively selective death of dopaminergic neurons in the substantia nigra of the brain. The vulnerability of these neurons appears to be linked to the pigment neuromelanin. However, as yet there is limited understanding behind the mechanisms of this disease process. Complications arise due to the difficulty in obtaining appreciable quantities of neuromelanin. Furthermore, an appropriate model for studying neuromelanin has not been identified. To date there has been many studies looking at the binding and chemical characteristics of neuromelanin. However, a range of different synthetic and organic melanins have been used as models and leading to many varied conclusions being drawn. Therefore, the aim of this review is to present Sepia melanin as the most appropriate study model for the binding characteristics of neuromelanin. Considerations included chemical structure, surface characteristics and structural features of both synthetic and organic melanins.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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Publication date: Available online 27 January 2020Source: The Lancet NeurologyAuthor(s): Franziska Hopfner, Günter U Höglinger, Gregor Kuhlenbäumer, Anton Pottegård, Mette Wod, Kaare Christensen, Caroline M Tanner, Günther DeuschlSummaryBackgroundβ-adrenoceptors are widely expressed in different human organs, mediate important body functions and are targeted by medications for various diseases (such as coronary heart disease and heart attack) and many β-adrenoceptor acting drugs are listed on the WHO Model List of Essential Medicines. β-adrenoceptor antagonists are used by billions ...
Source: The Lancet Neurology - Category: Neurology Source Type: research
We present a neurobiologically plausible elaboration of an existing schema-based cognitive model of action selection in which the basal ganglia implements an activation-based selection process that mediates between assumed cortical representations of rule-based schemas. More specifically, the model employs a network of basal ganglia units with computations performed by individual BG nuclei, embedded in a corticothalamic loop that disinhibits schemas according to the received feedback. We provide bridging assumptions for linking the operation of the model with ERP components that describe the error-related negativity (ERN) ...
Source: Neuropsychologia - Category: Neurology Source Type: research
Condition:   Parkinson Disease Interventions:   Other: 11C-UCB-J PET-CT;   Other: 18F-PE2I PET-MR Sponsor:   Universitaire Ziekenhuizen Leuven Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
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Source: mobihealthnews - Category: Information Technology Source Type: news
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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