Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin – A critical review
Publication date: March–April 2015 Source:Journal of Chemical Neuroanatomy, Volumes 64–65 Author(s): Rhiannon L. Schroeder , Kay L. Double , Jacobus P. Gerber Parkinson's disease is characterised pathologically by a relatively selective death of dopaminergic neurons in the substantia nigra of the brain. The vulnerability of these neurons appears to be linked to the pigment neuromelanin. However, as yet there is limited understanding behind the mechanisms of this disease process. Complications arise due to the difficulty in obtaining appreciable quantities of neuromelanin. Furthermore, an appropriate model for studying neuromelanin has not been identified. To date there has been many studies looking at the binding and chemical characteristics of neuromelanin. However, a range of different synthetic and organic melanins have been used as models and leading to many varied conclusions being drawn. Therefore, the aim of this review is to present Sepia melanin as the most appropriate study model for the binding characteristics of neuromelanin. Considerations included chemical structure, surface characteristics and structural features of both synthetic and organic melanins.
Publication date: Available online 27 January 2020Source: The Lancet NeurologyAuthor(s): Franziska Hopfner, Günter U Höglinger, Gregor Kuhlenbäumer, Anton Pottegård, Mette Wod, Kaare Christensen, Caroline M Tanner, Günther DeuschlSummaryBackgroundβ-adrenoceptors are widely expressed in different human organs, mediate important body functions and are targeted by medications for various diseases (such as coronary heart disease and heart attack) and many β-adrenoceptor acting drugs are listed on the WHO Model List of Essential Medicines. β-adrenoceptor antagonists are used by billions ...
We present a neurobiologically plausible elaboration of an existing schema-based cognitive model of action selection in which the basal ganglia implements an activation-based selection process that mediates between assumed cortical representations of rule-based schemas. More specifically, the model employs a network of basal ganglia units with computations performed by individual BG nuclei, embedded in a corticothalamic loop that disinhibits schemas according to the received feedback. We provide bridging assumptions for linking the operation of the model with ERP components that describe the error-related negativity (ERN) ...
Condition: Parkinson Disease Interventions: Other: 11C-UCB-J PET-CT; Other: 18F-PE2I PET-MR Sponsor: Universitaire Ziekenhuizen Leuven Recruiting
PARKINSON'S disease is a progressive nervous system disorder that affects movement. An obvious early sign of the disease is uncontrolled movements. Less obvious signs of the condition can appear when a person sleeps. What are they?
This study was registered with the Chinese Clinical Trial Registry under ChiCTR-TRC-14004707. Registered on May 27, 2014.
The spinal cord stimulation (SCS) market growth should improve in 2020 as leaders in the space launch new products and benefit from recent acquisitions and invest in potential indication expansions, according to Needham &Co.'s Mike Matson. The medtech analyst published a report Monday sharingÂ his takeaways from the North American Neuromodulation Society (NANS)Â meeting in Las Vegas, NV over the weekend. Matson noted that SCS device market growth should continue to improve in 2020 and beyond, thanks to a number of factors. The analyst estimates that SCS currently represents about $2.5 billion, whi...
The system may now be used to target patients'internal globus pallidus, a portion of the brain associated with Parkinson's disease symptoms.
By 'rewinding' cells of early-onset Parkinson's disease patients back to their stem cell states, a Cedars-Sinai study found that, even as embryos, theyhad abnormal dopamine neurons.
(Rutgers University) A collaboration between scientists at Rutgers University and Scripps Research leads to the discovery of a small molecule that may slow down or stop the progression of Parkinson's disease