TWiV 835: Giving thanks for antibodies

TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial. Click arrow to playDownload TWiV 835 (59 MB .mp3, 99 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology antibody coronavirus COVID-19 immune correlate of protection pandemic SARS-CoV-2 vaccine viral viruses Source Type: blogs

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In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
Chem Asian J. 2022 Jan 14:e202101215. doi: 10.1002/asia.202101215. Online ahead of print.ABSTRACTThe global COVID-19 pandemic has claimed the lives of millions and disrupted nearly every aspect of human society. Currently, vaccines remain the only widely available medical means to address the cause of the pandemic, the SARS-CoV-2 virus. Unfortunately, current scientific consensus deems the emergence of vaccine-resistant SARS-CoV-2 variants highly likely. In this context, the design and development of broad-spectrum, small-molecule based antiviral drugs has been described as a potentially effective, alternative medical stra...
Source: Chemistry, an Asian Journal - Category: Chemistry Authors: Source Type: research
Dr Maria Bottazzi says their vaccine, called Corbevax, is unique because they do not intend to patent itA new Covid-19 vaccine is being developed by Texas scientists using a decades-old conventional method that will make the production and distribution cheaper and more accessible for countries most affected by the pandemic and where new variants are likely to originate due to low inoculation rates.The team, led by Drs Peter Hotez and Maria Bottazzi from the Texas Children ’s Hospital Center for Vaccine Development at Baylor College of Medicine, has been developing vaccine prototypes for Sars and Mers since 2011, whic...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Texas Coronavirus Vaccines and immunisation US news World news Science Source Type: news
J Biomol Tech. 2021 Sep;32(3):89-97. doi: 10.7171/jbt.21-3203-003.ABSTRACTSurveillance screening at scale to identify people infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prior to extensive transmission is key to bringing an end to the coronavirus disease 2019 (COVID-19) pandemic, even though vaccinations have already begun. Here we describe Corona Detective, a sensitive and rapid molecular test to detect the virus, based on loop-mediated isothermal amplification, which could be applied anywhere at low cost. Critically, the method uses freeze-dried reagents, readily shipped without cold-chain dep...
Source: Journal of Biomolecular Techniques : JBT - Category: Molecular Biology Authors: Source Type: research
by Amy B. Rosenfeld I do not advocate testing for any person vaccinated against SARS-CoV-2 unless they display severe symptoms or live with those who for whom vaccines are not yet approved. I understand that testing and isolation are mechanisms to break virus transmission chains and were used at the beginning of the pandemic to […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology coronavirus COVID-19 pandemic SARS-CoV-2 viral viruses Source Type: blogs
Malay Sarkar, Irappa V Madabhavi, Pham Nguyen Quy, Manjunath B GovindagoudarAnnals of Thoracic Medicine 2022 17(1):1-13 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus responsible for the pandemic coronavirus disease 19 (COVID-19). It has significant impact on human health and public safety along with negative social and economic consequences. Vaccination against SARS-CoV-2 is likely the most effective approach to sustainably control the global COVID-19 pandemic. Vaccination is highly effective in reducing the risk of severe COVID-19 disease. Mass-scale vac...
Source: Annals of Thoracic Medicine - Category: Respiratory Medicine Authors: Source Type: research
In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID. Click arrow to playDownload TWiV 850 (58 MB .mp3, 48 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
Although not being the first viral pandemic to affect humankind, we are now for the first time faced with a pandemic caused by a coronavirus. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been responsible for the COVID-19 pandemic, which caused more than 4.5 million deaths worldwide. Despite unprecedented efforts, with vaccines being developed in a record time, SARS-CoV-2 continues to spread worldwide with new variants arising in different countries. Such persistent spread is in part enabled by public resistance to vaccination in some countries, and limited access to vaccines in other countries. The ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The global coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for more than 240 million infections and more than 4.8 million deaths up to October 17, 2021 [1]. While the number of people fully vaccinated against COVID-19 is globally increasing as several vaccines are available, there are still many active infections and the infectivity, transmission, and lethality of SARS-CoV-2 are evolving [2]. The emergence of new variants highlights the importance of surveillance systems to update vaccination strategies and treatment approaches [3].
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Source Type: research
Endocr Metab Immune Disord Drug Targets. 2022 Jan 10. doi: 10.2174/1871530322666220110113028. Online ahead of print.ABSTRACTCOVID-19, a pandemic caused by SARS-CoV2 has been spread all over the world and is responsible for serious fatalities. SARS-CoV2 is included in the family of β-coronavirus that affects pulmonary gas exchange and triggers cytokines storm. Vigorous inflammation, hyper-coagulation, a decrease in lymphocytic count and an increase in neutrophilic count are observed in the second week after the onset of disease. Fever, dry cough, sneezing, shortness of breath and respiratory distress are the symptoms o...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Source Type: research
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