Comparison and prioritization of antibiotics in a reservoir and its inflow rivers of Beijing, China

Environ Sci Pollut Res Int. 2021 Nov 27. doi: 10.1007/s11356-021-17723-9. Online ahead of print.ABSTRACTThe occurrence of antibiotics in drinking water resources, like reservoirs, is of considerable concern due to their potential risks to ecosystem, human health, and antimicrobial resistance development. Here, we quantified 83 antibiotics in water and sediments of wet and dry seasons from the Miyun reservoir and its inflow rivers in Beijing, China. Twenty-four antibiotics were detected in water with concentrations of ND-11.6 ng/L and 19 antibiotics were observed in sediments with concentrations of ND-6.50 ng/g. Sulfonamides (SAs) were the dominated antibiotics in water in two seasons. SAs and quinolones (QNs) in wet season and macrolides (MLs) and QNs in dry season predominated in sediments. The reservoir and inflow rivers showed significant differences in antibiotic concentrations and compositions in water and sediments. As an important input source of reservoir, the river water showed significantly higher total antibiotic concentrations than those in the reservoir. In contrast, the reservoir sediments are the sink of antibiotics, and had higher total antibiotic concentrations compared with rivers. A prioritization approach based on the overall risk scores and detection frequencies of antibiotics was developed, and 3 (sulfaguanidine, anhydroerythromycin, and sulfamethoxazole) and 5 (doxycycline, sulfadiazine, clarithromycin, roxithromycin, and flumequine) antibiotics with hi...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Source Type: research

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This study aims to discuss the global problem of antimicrobial resistance that has been amplified by international travel and explore stewardship considerations for providers when caring for travelers.Recent FindingsThere are a variety of environmental and societal factors that contribute to the ongoing development and spread of antimicrobial resistance. Now more than ever, there are increasing rates of international travelers each year in the context of similarly rising rates of multi-drug-resistant organisms. With global travel, individuals are at risk for infection and colonization with these multi-drug-resistant organi...
Source: Current Treatment Options in Infectious Diseases - Category: Infectious Diseases Source Type: research
a R. Kassab The growing risk of antimicrobial resistance besides the continuous increase in the number of cancer patients represents a great threat to global health, which requires intensified efforts to discover new bioactive compounds to use as antimicrobial and anticancer agents. Thus, a new set of pyridothienopyrimidine derivatives 2a,b–9a,b was synthesized via cyclization reactions of 3-amino-thieno[2,3-b]pyridine-2-carboxamides 1a,b with different reagents. All new compounds were evaluated against five bacterial and five fungal strains. Many of the target compounds showed significant antimicrobial activ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
As COVID-19 rages on, the pandemic of antimicrobial resistance (AMR) continues in the shadows. The toll taken by AMR on patients and their families is largely invisible but is reflected in prolonged bacterial infections that extend hospital stays and cause needless deaths. 1 Moreover, AMR disproportionately affects poor individuals who have little access to second-line, more expensive antibiotics that could work when first-line drugs fail. Previous attempts have been made to accurately estimate the global burden of AMR, both to focus policy makers on the extent of the problem and to identify geographical areas with the ...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Antimicrobial resistance (AMR) poses a major threat to human health around the world. Previous publications have estimated the effect of AMR on incidence, deaths, hospital length of stay, and health-care costs for specific pathogen –drug combinations in select locations. To our knowledge, this study presents the most comprehensive estimates of AMR burden to date.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Emerg Infect Dis. 2022 Feb;28(2):382-393. doi: 10.3201/eid2802.211491.ABSTRACTEdema disease is an often fatal enterotoxemia caused by specific strains of Shiga toxin-producing Escherichia coli (STEC) that affect primarily healthy, rapidly growing nursery pigs. Recently, outbreaks of edema disease have also emerged in France in wild boars. Analysis of STEC strains isolated from wild boars during 2013-2019 showed that they belonged to the serotype O139:H1 and were positive for both Stx2e and F18 fimbriae. However, in contrast to classical STEC O139:H1 strains circulating in pigs, they also possessed enterotoxin genes sta1 an...
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Eur J Intern Med. 2022 Jan 21:S0953-6205(22)00039-5. doi: 10.1016/j.ejim.2022.01.029. Online ahead of print.ABSTRACTThe incidence of infections caused by bacteria that are resistant to antibiotics is constantly increasing. In Europe alone, it has been estimated that each year about 33'000 deaths are attributable to such infections. One important driver of antimicrobial resistance is the use and abuse of antibiotics in human medicine. Inappropriate prescribing of antibiotics is still very frequent: up to 50% of all antimicrobials prescribed in humans might be unnecessary and several studies show that at least 50% of antibio...
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Source Type: research
CONCLUSION: This study is the first to determine the complete sequence of a blaIMP-10-carrying plasmid, and this is also the first report of a blaIMP-10-producing strain in China. The prevalence of the blaIMP-10 gene and the genetic characterization of the blaIMP-10-carrying plasmid should be analyzed to provide deeper insight into the transmission mechanism of antimicrobial resistance genes.PMID:35077675 | DOI:10.1016/j.actatropica.2022.106326
Source: Acta Tropica - Category: Infectious Diseases Authors: Source Type: research
CONCLUSIONS: Our study suggests a portion of pain physicians do not adhere to the Neuromodulation Appropriateness Consensus Committee (NACC) guidelines in regards to antibiotic administration for SCS trial and implantation. Further analysis and surveys would allow insight into common practices. More information and education would be beneficial to optimize peri-procedure antibiotic use to reduce infection risk and decrease antimicrobial resistance.PMID:35075422 | PMC:PMC8782197 | DOI:10.5812/aapm.120611
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
This study presented a short linear antimicrobial peptide RW-BP100-4D, which was derived from RW-BP100 (RRLFRRILRWL-NH2) by transforming the N-terminal 4th amino acid from L- to D-enantiomer. This modification remarkably reduced the peptide cytotoxicity to mammalian cells, as indicated by hemolytic and cytotoxicity assays. Meanwhile, the antimicrobial activity of RW-BP100-4D was improved against a more variety of Gram-positive and Gram-negative bacteria (sensitive and resistant) as well as fungi. Also, RW-BP100-4D showed strong in vitro anti-biofilm activity in a concentration-dependent manner, including inhibition of the ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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