Maternal and neonatal outcomes following in vitro fertilization: A cohort study in Romania

In conclusion, this cohort study showed that IVF pregnancies have a higher risk of obstetric and neonatal complications than pregnancies obtained by spontaneous conception.PMID:34824642 | PMC:PMC8611488 | DOI:10.3892/etm.2021.10956
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research

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In conclusion, this cohort study showed that IVF pregnancies have a higher risk of obstetric and neonatal complications than pregnancies obtained by spontaneous conception.PMID:34824642 | PMC:PMC8611488 | DOI:10.3892/etm.2021.10956
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
ConclusionsFew women used PDE5 inhibitors in outpatient settings before or during pregnancy in the Scandinavian countries in the last decades. Only a small proportion had a diagnosis for pulmonary arterial hypertension, suggesting off-label use in the remaining users. Use was predominantly in mothers over age 35  years. The safety of fetal exposure to sildenafil and other PDE5 inhibitors in pregnancy has not been established. As maternal age continues to increase and additional uses of PDE5 inhibitors are investigated, the safety of these drugs in pregnancy should be thoroughly evaluated.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
In conclusion, PCOS appeared to result in an increased risk of adverse pregnancy complications. Obesity may further increase the risks of hypertension and GDM among women with PCOS. However, ART did not increase the risk of pregnancy complications, which suggests that ART is a relatively safe and effective method to address infertility problems in women with PCOS.IMPACT STATEMENTWhat is already known on this subject? There are several studies evaluating the associations of PCOS with the risk of pregnancy complications. However, reports about the risk of pregnancy complications between PCOS women with and without obesity or...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Source Type: research
AbstractStudy questionFrozen embryo transfer (FET) of euploid blastocysts in hormone replacement therapy (HRT) or natural cycle (NC): are there differences in obstetric, fetal and neonatal outcomes?Summary answerPregnancy complications, neonatal outcomes and fetal abnormalities are not increased after FET with PGT-A in singleton pregnancies.What is known alreadySince its introduction, PGT has been widely used in ART centers for preventing chromosomal and monogenic diseases. Despite its increased use, there are scarce and conflicting data about adverse pregnancy, fetal and neonatal outcomes. In one published study, the risk...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionDo preimplantation genetic testing (PGT) pregnancies have higher pregnancy and delivery complications compared to naturally conceived (NC) pregnancies?Summary answerPGT pregnancies do not have increase pregnancy complications but do have increased post-partum complications.What is known alreadyThere is limited data about the outcome of PGT cycles regarding pregnancy complications.Previous reports show that PGT pregnancies are similar to NC pregnancies regarding birth weight and preterm delivery rate.Patients performing PGT are less likely to have infertility as a background problem, and therefore it i...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionIs hormone replacement therapy cycle (HRT) associated with a higher risk of adverse perinatal outcomes than natural cycle (NC) during frozen embryo transfer (FET)?Summary answerHigher rates of hypertensive disorders of pregnancy (HDPs) and macrosomia were detected in HRT-FET as compared to NC-FET in ovulatory women.  What is known alreadyLive-birth rates after HRT-FET and NC-FET are found to be comparable. Recent data showed that pregnancies following HRT-FET are associated with higher risks of HDPs. However, the results might be influenced by selection bias as patients with ovulation disorder we...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionDoes an elevated SDF (>15%) increase the odds of adverse maternal and neonatal outcomes in autologous oocyte IVF-ICSI cycles from unselected couples?Summary answerNo adverse effects of high SDF on obstetric and neonatal outcomes have been found in couples with sperm fragmentation undergoing IVF-ICSI cycles with own eggs.What is known alreadySperm chromatin integrity assessment has been implemented as an additional tool in the clinical evaluation of sperm quality in infertile patients undergoing an assisted reproduction treatment. All of the published reports to date appraise its effect on clinical ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionAre pregnancies after embryo donation (ED) at higher risk of complications than those issued from autologous frozen-thawed embryo transfer (FET)?Summary answerEven in young women, the risk of pregnancy induced hypertension (PIH) is four time higher in pregnancies after ED versus controls.What is known alreadyAfter oocyte donation, a higher risk of PIH is well described. It is more controversial after sperm donation. The risk origin remains uncertain, even though an immunological explanation seems most likely. In ED, the fetus being fully allogeneic to his parents may be less well-tolerated. Very few d...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionWhat are the available preconception care policies, guidelines, recommendations and services as well as infertility care in South America ?Summary answerPreconception recommendations offered by both governament and medical societies in South America were fragmented and inconsistent and public fertility care is available in seven countries.What is known alreadyPromoting preconception health can potentially improve women ’s health and pregnancy outcomes. Evidence-based interventions exist to reduce many maternal behaviors and chronic conditions that are associated with adverse pregnancy outcomes s...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
CONCLUSIONS: TC history did not affect the pregnancy outcomes or increase the risk of adverse obstetric outcomes after the first IVF/ICSI, but it may decrease the number of retrieved oocytes and high-grade embryos.PMID:34088310 | DOI:10.1186/s12958-021-00763-8
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Source Type: research
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