Is living in a region with high groundwater arsenic contamination associated with adverse reproductive health outcomes? An analysis using nationally representative data from India

Int J Hyg Environ Health. 2021 Nov 24;239:113883. doi: 10.1016/j.ijheh.2021.113883. Online ahead of print.ABSTRACTBACKGROUND: Exposure to groundwater arsenic via drinking water is common in certain geographies, such as parts of India, and causes a range of negative health effects, potentially including adverse reproductive health outcomes.METHODS: We conducted an ecological analysis of self-reported rates of stillbirth, recurrent pregnancy loss, and infertility in relation to groundwater arsenic levels in India. We used a gridded, modeled dataset of the probability of groundwater arsenic exceeding 10 μg/L (World Health Organization drinking water limit) to calculate mean probabilities at the district level (n = 599 districts). A spatial integration approach was used to merge these estimates with the third India District-Level Health Survey (DLHS-3) conducted in 2007-08 (n = 643,944 women of reproductive age). Maps of district level arsenic levels and rates of each of the three outcomes were created to visualize the patterns across India. To adjust for significant spatial autocorrelation, spatial error models were fit.FINDINGS: District-level analysis showed that the average level of stillbirth was 4.3%, recurrent pregnancy loss was 3.3%, and infertility was 8.1%. The average district-level probability of groundwater arsenic levels exceeding 10 μg/L was 42%. After adjustment for sociodemographic factors, and accounting for spatial dependence, at the district level, for e...
Source: International Journal of Hygiene and Environmental health - Category: Environmental Health Authors: Source Type: research

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Bacterial vaginosis (BV) is a common infection in women of reproductive age and is estimated to have a prevalence of 29.2% in the United States. BV is often asymptomatic but has been linked with pelvic inflammatory disease and preterm delivery. BV has also been associated with an increased risk of sexually transmitted infections (STIs) including Chlamydia trachomatis, Neisseria gonorrhoeae, and human immunodeficiency virus. Mycoplasma genitalium is an emerging STI that has been associated with pelvic inflammatory disease, infertility, and adverse birth outcomes.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Source Type: research
Individuals with moderate to severe depressive symptoms are more likely to say they believe misinformation about COVID-19 vaccines than those without depressive symptoms, according to areport in JAMA Open Network. Moreover, individuals who believed misinformation about COVID vaccines were less likely to be vaccinated or be willing to get the vaccine.“As such, individuals already burdened with depression may be at a higher risk of COVID-19,” wrote lead author Roy H. Perlis, M.D., M.Sc., of Massachusetts General Hospital and colleagues.The researchers analyzed data from U.S. adults who responded to at least one o...
Source: Psychiatr News - Category: Psychiatry Tags: APA election COVID COVID vaccine depression JAMA Network Open misinformation survey U.S. adults Source Type: research
Asian J Androl. 2022 Jan 21. doi: 10.4103/aja2021109. Online ahead of print.ABSTRACTDuring recent decades, the association between mutations in ubiquitin-specific protease 26 (USP26) and male infertility remains doubtful. We conducted this meta-analysis to evaluate the association between mutations in USP26 and male infertility according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. It was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42021225251). PubMed, Web of Science, and Scopus were systematically searched for comparative ...
Source: Asian Journal of Andrology - Category: Urology & Nephrology Authors: Source Type: research
Experimental &Molecular Medicine, Published online: 25 January 2022; doi:10.1038/s12276-021-00722-8Identification of a hormone-sensitive signaling pathway in a subset of ovarian cells could lead to better treatment for women experiencing adverse events associated with infertility treatment. Up to 8% of women who receive the ‘pregnancy hormone’ human chorionic gonadotropin (hCG) during fertility care will develop ovarian hyperstimulation syndrome (OHSS), a condition that can be debilitating or even fatal. Researchers led by Qinju Chen of Shanghai JiaoTong University and Shaorong Gao of Tongji University, Sha...
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
AbstractBackgroundBeneficial effects of hyaluronic acid (HA)-based selection of spermatozoa for intracytoplasmic sperm injection (ICSI) are still controversial and further studies are needed to categorize patients that might benefit from such a method.ObjectiveWe investigated whether HA sperm selection improved ICSI outcome of couples with previous ICSI cycle failure.Materials and MethodsIn this retrospective study we prospectively collected data of i) Group 1: 96 couples who performed one failed ICSI cycle ( “1st procedure ”, n = 96) followed by another ICSI cycle (“2nd procedure ”, n = 101); ii) G...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSIONS: A careful selection of patients allowed us to confirm that women affected by idiopathic infertility show a high prevalence of aPL, suggesting that these autoantibodies can also affect conception. Considering pregnancy complications and thrombotic risk related to ovarian stimulation, measuring aPL can represent a valid tool to identify among infertile women undergoing ART those at higher risk of pregnancy complications potentially life-threatening for mother and the fetus. In such patients, an accurate diagnosis and an adequate therapy are related to a better ART outcome.PMID:35073215 | DOI:10.1177/09612033221076735
Source: Lupus - Category: Rheumatology Authors: Source Type: research
ObjectiveTo investigate the effects of endometrial thickness (EMT) on pregnancy outcomes on hCG trigger day in fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles.MethodsA total of 42,132 fresh cycles between 1 January 2013 and 31 December 2019 were included in this retrospective cohort study. Data were collected from five reproductive centers of large academic or university hospitals in China. All patients were divided into different groups according to their endometrial thickness on hCG trigger day. Multivariate regression analysis, curve fitting and threshold effect analysis were p...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This study aimed to evaluate the efficacy and safety of calcium ionophore during assisted oocyte activation (AOA). This meta-analysis contained randomized controlled trials and prospective observational and retrospective trials. The summary odds ratio (OR) with 95% confidence intervals (CIs) was calculated for clinical pregnancy rate and live birth rate. Both fixed and random effects models were applied. A total of 22 studies were included into this meta-analysis. Seventeen of the included studies showed that calcium ionophore increased the clinical pregnancy rate (OR, 2.14; 95% CI, 1.38–3.31). Similarly, 14 studies ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ConclusionThe current evidence is inconclusive on whether endometriomas should be surgically removed prior to ART. Further large randomized controlled trials are needed for a definite answer, and until then, management should be individualized.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionEndometrial plasma cells are present in half the general infertile population and do not predict implantation, clinical pregnancy, clinical pregnancy loss, or live birth rates at low levels.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
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