Experience with ustekinumab in reservoir Crohn's disease

Rev Esp Enferm Dig. 2021 Nov 25. doi: 10.17235/reed.2021.8457/2021. Online ahead of print.ABSTRACTCrohn's disease of the reservoir is a pathology of difficult diagnosis and complex approach due to the scarce documented evidence on it. Recently, studies have been published on the treatment strategies available for this entity. Based on the above, we have analyzed the experience of our center in the treatment of reservoir Crohn's disease with one of the new biologic agents, ustekinumab.PMID:34818897 | DOI:10.17235/reed.2021.8457/2021
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Authors: Source Type: research

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Condition:   Crohn's Disease Intervention:   Other: No Intervention Sponsor:   Takeda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study was performed to investigate the clinical roles of PR3-ANCAs in the disease severity, disease extension, and clinical course of UC.METHODS: Serum PR3-ANCAs were measured in 173 UC patients including 77 patients with new-onset patients UC diagnosed within 1 month, 110 patients with Crohn's disease, 48 patients with other intestinal diseases, and 71 healthy controls. Associations between the PR3-ANCA titer and clinical data, such as disease severity, disease extension, and clinical course, were assessed. The clinical utility of PR3-ANCA measurement was evaluated by receiver operating characteristic (ROC) analysis....
Source: Gut and Liver - Category: Gastroenterology Authors: Source Type: research
Rom J Morphol Embryol. 2021 Apr-Jun;62(2):395-400. doi: 10.47162/RJME.62.2.05.ABSTRACTUlcerative colitis and Crohn's disease are the inflammatory bowel diseases with a continuously increasing of prevalence. Their exact causes are still not well known and, more than that, they are raising up serious issues of diagnosis. The same difficulties of diagnosis are encountered in the case of the colonic angiodysplasia or ischemic colitis (IC). Colonic angiodysplasia is a common vascular abnormality of the gastrointestinal tract, being diagnosed mostly in the elderly persons, in a similar manner to the IC. For all these diseases co...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Authors: Source Type: research
Am Surg. 2022 Jan 13:31348211054521. doi: 10.1177/00031348211054521. Online ahead of print.ABSTRACTSmall bowel perforation is an uncommon but severe event in the natural history of Crohn's disease with fewer than 100 cases reported. We review Crohn's disease cases with necrotizing enteritis and share a case of a 26-year-old female who presented with a recurrent episode of small intestinal perforation. A PubMed literature review of case reports and series was conducted using keywords and combinations of "Crohn's disease," "small intestine perforation," "small bowel perforation," "free perf...
Source: The American Surgeon - Category: Surgery Authors: Source Type: research
Background: Crohn ’s disease (CD) is a condition on the spectrum of inflammatory bowel disease that affects up to 20 people per 100,000 in the US annually, and with incidence increasing. One of the most significant sources of morbidity in CD is the formation of strictures, with resultant intestinal blockage a commo n indication for hospitalization and surgical intervention in these patients. The pathophysiology of stricture formation is not fully understood. However, the fibroplasia that leads to fibrostenotic stricture formation may have shared pathophysiology with IgG4-related fibrosis.Summary: Initial intestinal i...
Source: Pathobiology - Category: Pathology Source Type: research
Conditions:   Ulcerative Colitis Chronic;   Crohn Disease Colon Intervention:   Other: No intervention Sponsors:   Kazakhstan Scientific Society for Study of intestine diseases;   FERRING Kazakhstan Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS Although the analysis did not reveal any risk factors for perioperative complications, perianal manifestations, penetrating disease type, ileal/ileocecal involvement, and smoking may be associated with risk of earlier surgery or multiple surgeries.PMID:35017460 | DOI:10.12659/MSM.934463
Source: Medical Science Monitor - Category: Research Authors: Source Type: research
Conclusion: Expanding anti-TNF therapy use among US adult patients with moderate-to-severe Crohn's disease would reduce morbidity and mortality, decrease disease-related medical costs and increase treatment costs compared with current practice. Despite the higher costs, this approach could substantially benefit patients.PMID:35014551 | DOI:10.2217/cer-2021-0063
Source: Journal of Comparative Effectiveness Research - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: available objective data to guide nutritional support and primary nutritional therapy in IBD are presented as 64 recommendations, of which 9 are very strong recommendations (grade A), 22 are strong recommendations (grade B), and 12 are based only on sparse evidence (grade 0); 21 recommendations are good practice points (GPP).PMID:35014851 | DOI:10.20960/nh.03857
Source: Nutricion Hospitalaria - Category: Nutrition Authors: Source Type: research
Conclusion: Expanding anti-TNF therapy use among US adult patients with moderate-to-severe Crohn's disease would reduce morbidity and mortality, decrease disease-related medical costs and increase treatment costs compared with current practice. Despite the higher costs, this approach could substantially benefit patients.PMID:35014551 | DOI:10.2217/cer-2021-0063
Source: Journal of Comparative Effectiveness Research - Category: General Medicine Authors: Source Type: research
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