Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study

Conclusions: The plasma APE1/Ref-1 level increased during surgery with more severe lymph node invasion, but there were no significant differences according to the anesthetics used.PMID:34833498 | DOI:10.3390/medicina57111280
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Source Type: research

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AbstractAccurate staging and re-staging of cancer in children is crucial for patient management. Currently, children with a newly diagnosed cancer must undergo a series of imaging tests, which are stressful, time-consuming, partially redundant, expensive, and can require repetitive anesthesia. New approaches for pediatric cancer staging can evaluate the primary tumor and metastases in a single session. However, traditional one-stop imaging tests, such as CT and positron emission tomography (PET)/CT, are associated with considerable radiation exposure. This is particularly concerning for children because they are more sensi...
Source: Pediatric Radiology - Category: Radiology Source Type: research
This study aimed to explore the characteristics of and related risk factors for Horner syndrome after ICNB.STUDY DESIGN: A prospective, nested case-control study.SETTING: Fudan University Shanghai Cancer Centre from April 2020 through July 2020.METHODS: Patients scheduled for breast lumpectomy under ICNB from April 2020 through July 2020 in our hospital were recruited. The ICNB was introduced at the intersection of the midaxillary line and the inferior border of the ribs, according to the location of the mass. Horner syndrome indicators were assessed one, 5, 10, 15, 30, 45, and 60 minutes and 3, 6, 12 and 24 hours after IC...
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
Recent Pat Anticancer Drug Discov. 2022 Jan 19. doi: 10.2174/1574892817666220119121204. Online ahead of print.ABSTRACTLocal anesthetics are voltage-gated sodium channel blockers primarily administered locally or to the innervating nerves for anesthetic or analgesic purposes. In vitrol studies have found direct effects of local anesthetics on cancer cell, such as impacts on cancer cell proliferation, apoptosis, migration, invasion, and chemosensitivity, which involved multiple mechanisms. So far, in vivo evidence in the effect of local anesthetics on cancer cell lines is relatively lacking. Local and regional anesthesia adm...
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Authors: Source Type: research
This study aimed to evaluate short-term outcomes of robot-assisted McKeown esophagectomy (RAME) and video-assisted McKeown esophagectomy (VAME). All consecutive patients undergoing minimally invasive McKeown esophagectomy for middle and distal third esophageal cancer between January 2016 and December 2018 at our center were included in this study. Data on baseline characteristics, pathological data and short-term outcomes were collected in a dedicated database. Postoperative complications were defined as per recommendations of Esophagectomy Complications Consensus Group. Histopathologic assessment was performed as per Coll...
Source: Journal of Robotic Surgery - Category: Surgery Source Type: research
CONCLUSION: DEX can reduce postoperative OS and plasma miR-10a level in patients with lung cancer, and high expression of miR-10a predicts a high incidence of postoperative pulmonary complications.PMID:35042243 | DOI:10.1055/s-0041-1740558
Source: The Thoracic and Cardiovascular Surgeon - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Am J Transl Res. 2021 Dec 15;13(12):14211-14219. eCollection 2021.ABSTRACTOBJECTIVE: To explore the significance of CYP3A4 and CYP3A5 genetic polymorphisms in achieving personalized fentanyl application in patients undergoing thoracoscopic operation.METHODS: This was a retrospective study. One hundred patients with lung cancer received thoracoscopic surgery operation under the conditions of general anesthesia. According to the results of individualized analgesia guided by CYP3A4/5 polymorphisms, the patients were assigned into three groups: group I (the wild-type homozygote, the induced dosage of fentanyl: 6 µg/kg, t...
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
Anaesthesia. 2022 Jan 17. doi: 10.1111/anae.15651. Online ahead of print.ABSTRACTEffective pain control enhances patient recovery after surgery. Laparoscopic techniques for major abdominal surgery are increasingly utilised to reduce surgical trauma. Intrathecal morphine is an attractive analgesic option that is gaining popularity. However, limited evidence guides its use in the setting of laparoscopic surgery. In addition, enhanced recovery after surgery pathways advocate opioid-sparing techniques. We conducted a feasibility trial to compare intrathecal morphine with non-neuraxial analgesia in laparoscopic or laparoscopic-...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Am J Transl Res. 2021 Dec 15;13(12):14211-14219. eCollection 2021.ABSTRACTOBJECTIVE: To explore the significance of CYP3A4 and CYP3A5 genetic polymorphisms in achieving personalized fentanyl application in patients undergoing thoracoscopic operation.METHODS: This was a retrospective study. One hundred patients with lung cancer received thoracoscopic surgery operation under the conditions of general anesthesia. According to the results of individualized analgesia guided by CYP3A4/5 polymorphisms, the patients were assigned into three groups: group I (the wild-type homozygote, the induced dosage of fentanyl: 6 µg/kg, t...
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
ConclusionAnalyses of our cohort’s data suggest that planned awake surgery might not have a negative impact on patients concerning the prevalence and severity of manifestation of distress, anxiety, or depression in psychooncological screening. Patients undergoing recurrent surgery tend to demonstrate increased distress, although results were not significant.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Clin Colon Rectal Surg 2022; 35: 051-057 DOI: 10.1055/s-0041-1740038Perianal fistulizing Crohn's disease represents a severe phenotype associated with significant morbidity. Patients with perianal fistulizing disease are more likely to have a severe disease course and have significant reductions in quality of life. Moreover, these patients are at risk for the development of distal rectal and anal cancers. Given the complexity and severity of this patient group, the management of perianal Crohn's disease must be undertaken by a multidisciplinary team. The gastroenterologist and colorectal surgeon play a critical role in the...
Source: Clinics in Colon and Rectal Surgery - Category: Surgery Authors: Tags: Review Article Source Type: research
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