Prevalence of recreational substance use in patients presenting with seizures to a tertiary care hospital

CONCLUSIONS: Overall, the most common concomitantly positively tested RSU during seizure encounters was cannabinoid (40.7%) followed by benzodiazepine (38.7%). There was a higher proportion of males' encounters with concomitant seizure and RSU regardless of type of drug class. Amphetamine use was more common in Caucasians, while the remaining studied RSU were more common in African Americans. Similar trends were seen in the subgroup of subjects older than 16 years.PMID:34837845 | DOI:10.1016/j.yebeh.2021.108419
Source: Epilepsy and Behaviour - Category: Neurology Authors: Source Type: research

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Funding comes from CURE Epilepsy Foundation and the Cameron Boyce Foundation, named for Disney Channel actor who died at age 20.
Source: SUNY Upstate Medical - Category: Universities & Medical Training Tags: News Source Type: news
Condition:   Epilepsy Intervention:   Behavioral: Dimension-Based Statistical Learning Sponsors:   University of Pittsburgh;   National Institutes of Health (NIH);   Carnegie Mellon University;   National Institute on Deafness and Other Communication Disorders (NIDCD) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We describe a case of late HSE relapse after epilepsy surgery in a patient who required a brain biopsy due to repeated negative CSF-PCR results. A 38-year-old woman had a history of HSE from the age of 3 years. She had intractable epilepsy from the age of 20 years and underwent right posterior quadrant disconnection (PQD) at the age of 38 years. Postoperatively, she had a right hemispheric intracerebral hemorrhage (ICH) and her consciousness was gradually worsening. Her consciousness improved after removal of the ICH. However, her consciousness gradually deteriorated again. Fluid-attenuated inversion recovery (FLAIR) revea...
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research
This article reviews the data for clinical and electrographic seizures associated with COVID-19, technical EEG considerations for reducing risk of transmission, and factors contributing to seizure exacerbations in PWE as well as strategies to address this issue.RECENT FINDINGS: An increasing number of studies of larger cohorts, accounting for a variety of variables and often utilizing EEG with standardized terminology, are assessing the prevalence of seizures in hospitalized patients with acute COVID-19 infections, and gaining insight into the prevalence of seizures and their effect on outcomes. Additionally, recent studie...
Source: Epilepsy Curr - Category: Neurology Authors: Source Type: research
Voltage-gated sodium channel genes are an important family of human epilepsy genes. De novo missense mutations in SCN8A (encoding Nav1.6) are associated with a spectrum of clinical presentation, including multiple seizure types, movement disorders, intellectual disability, and behavioral abnormalities such as autism. Patients with SCN8A mutations are often treated with multiple antiepileptic drugs, the most common being sodium channel blockers. Cannabidiol (CBD) has been included as a component of treatment regimens for some SCN8A patients; however, to date, there are no clinical trials that have evaluated the therapeutic ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This article reviews the data for clinical and electrographic seizures associated with COVID-19, technical EEG considerations for reducing risk of transmission, and factors contributing to seizure exacerbations in PWE as well as strategies to address this issue.Recent FindingsAn increasing number of studies of larger cohorts, accounting for a variety of variables and often utilizing EEG with standardized terminology, are assessing the prevalence of seizures in hospitalized patients with acute COVID-19 infections, and gaining insight into the prevalence of seizures and their effect on outcomes. Additionally, recent studies ...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
ConclusionIn conclusion, CVI can be considered as a major feature of CDD with a diffuse involvement in several behavioral and electrophysiological aspects. Larger cohorts will help to better clarify the possible prognostic role of EEG severity in predicting both visual and developmental abnormalities.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Condition:   COVID-19 Intervention:   Other: Non Sponsor:   Aswan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Prog Brain Res. 2022;268(1):329-345. doi: 10.1016/bs.pbr.2021.10.040. Epub 2021 Dec 15.ABSTRACTGKNS has been introduced as an alternative to microsurgery for the treatment of certain types of focal epilepsy. It was first noted that epilepsy associated with AVMs often improved before the obliteration of the vascular lesion. It was subsequently shown that the treatment could be effective in mesial temporal lobe epilepsy (MTLE) producing remission in around 60% of patients, provided the treatment was carried out as originally designed. GKNS has also been useful in the treatment of gelastic epilepsy associated with hypothalami...
Source: Brain Research - Category: Neurology Authors: Source Type: research
Stem Cell Res. 2022 Jan 19;60:102673. doi: 10.1016/j.scr.2022.102673. Online ahead of print.ABSTRACTIn this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.PMID:35074713 | DOI:10.1016/j.scr.2022.102673
Source: Cell Research - Category: Cytology Authors: Source Type: research
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