Immunization with recombinant ORF2 p551 protein protects common marmosets (Callithrix jacchus) against homologous and heterologous hepatitis E virus challenge

CONCLUSIONS: CMs are shown to be a convenient laboratory animal model susceptible to infection with HEV GT1 and GT3. Immunization with HEV GT3 ORF2/p551 triggers potent anti-HEV antibody response protecting CMs from homologous and heterologous HEV challenge. This advances p551 in VLPs as a prototype vaccine against HEV.PMID:34836660 | DOI:10.1016/j.vaccine.2021.11.042

Source: Vaccine - November 27, 2021 Category: Allergy & Immunology Authors: Ilya Gordeychuk Karen Kyuregyan Alla Kondrashova Ekaterina Bayurova Stanislav Gulyaev Tatiana Gulyaeva Ilya Potemkin Anastasia Karlsen Olga Isaeva Alla Belyakova Anna Lyashenko Alexey Sorokin Alexey Chumakov Igor Morozov Maria Isaguliants Aydar Ishmukhame Source Type: research