Inflammatory markers of perinatal depression in women with and without history of trauma

CONCLUSIONS: History of trauma was associated with a more severe clinical phenotype of PND and decreased resilience level. The increase of acute phase proteins in women with PND and higher TNF-a level in those with trauma exposure validated the inflammatory theory of PND. Our findings substantiated the need of implementing the screening of pregnant women with the assessment of trauma history. Properly, resilience-enhancing interventions are recommended with the aim of support mothers and mitigate the possible transgenerational transmission of pathology. The biological results are compelling although preliminary.PMID:34663990 | DOI:10.1708/3681.36671
Source: Rivista di Psichiatria - Category: Psychiatry Authors: Source Type: research