Crohn’s disease: The colour of your poo warning you may be at risk – what to spot?

CROHN'S disease is the painful digestive condition with unusual warning signs. The colour of your poo being one of them. What to look out for?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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CONCLUSIONS: The Norwegian version of MFI-20 is valid, reliable and responsive. The instrument can safely be used in studies using fatigue as an endpoint.PMID:35076321 | DOI:10.1080/00365521.2022.2029939
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Condition:   Sacroiliitis Intervention:   Procedure: MRI scan Sponsors:   NYU Langone Health;   Spondyloarthritis Research and Treatment Network Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
World J Gastroenterol. 2021 Dec 21;27(47):8047-8057. doi: 10.3748/wjg.v27.i47.8047.ABSTRACTInflammatory bowel disease (IBD) is a chronic condition that requires continuous medical treatment. To date, the medical management of patients with moderately-to-severely active IBD who develop dependence or resistance to corticosteroids is based on immunomodulator drugs. Such therapies are licenced after passing through three phases of randomized controlled trials (RCTs), and are subsequently adopted in clinical practice. However, the real-life population of IBD patients who require these therapies can significantly differ from tho...
Source: World Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
World J Gastroenterol. 2021 Dec 21;27(47):8040-8046. doi: 10.3748/wjg.v27.i47.8040.ABSTRACTHelicobacter pylori (H. pylori) infection causes changes to the intestinal flora, such as small intestinal bacterial overgrowth, and increases gastric acid secretion-stimulating gastrointestinal hormones, mainly gastrin, due to a decrease in gastric acid caused by atrophic gastritis. In addition, the cellular components of H. pylori travel through the intestinal tract, so the bacterial infection affects the immune system. Therefore, the effects of H. pylori infection are observed not only in the stomach and the proximal duodenum but ...
Source: World Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
CONCLUSIONS: In this large study among older adults (≥66 years of age), IBD was positively associated with gastrointestinal cancers. Associations with extraintestinal cancers may reflect the effect of immunosuppressive medications.PMID:35071980 | PMC:PMC8767622 | DOI:10.1093/jncics/pkab096
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
World J Hepatol. 2021 Dec 27;13(12):1828-1849. doi: 10.4254/wjh.v13.i12.1828.ABSTRACTHepatobiliary disorders are among the most common extraintestinal manifestations in inflammatory bowel diseases (IBD), both in Crohn's disease and ulcerative colitis (UC), and therefore represent a diagnostic challenge. Immune-mediated conditions include primary sclerosing cholangitis (PSC) as the main form, variant forms of PSC (namely small-duct PSC, PSC-autoimmune hepatitis overlap syndrome and IgG4-related sclerosing cholangitis) and granulomatous hepatitis. PSC is by far the most common, presenting in up to 8% of IBD patients, more fr...
Source: World Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Exp Ther Med. 2022 Feb;23(2):149. doi: 10.3892/etm.2021.11072. Epub 2021 Dec 16.ABSTRACTIntestinal strictures are an important complication of Crohn's disease (CD), with ~40% of patients developing symptomatic obstruction within 10 years of diagnosis. However, there is a paucity of research examining the mechanisms driving the development of fibrotic strictures in CD. The present study aimed to identify the mucosal markers associated with stricturing complications by examining the differences in the gene expression profiles of two patient cohorts: Patients diagnosed with inflammatory CD (n=12) and patients with stricturing...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
Clin Colon Rectal Surg. 2022 Jan 17;35(1):72-77. doi: 10.1055/s-0041-1740031. eCollection 2022 Jan.ABSTRACTThe deeper understanding of the inflammatory process which gradually evolves into irreversible fibrosis and tissue damage has provided a precise picture of the disease course of luminal ileocecal Crohn's disease. According to the model of progressive structural damage, ideal time windows for medical and surgical treatment have been identified. While complicated disease clearly profits from surgical treatment, uncomplicated disease has become, in the last years, the most debatable setting in terms of different approach...
Source: Hand Surgery - Category: Surgery Authors: Source Type: research
Adv Biomed Res. 2021 Nov 26;10:39. doi: 10.4103/abr.abr_180_19. eCollection 2021.ABSTRACTExtraintestinal manifestations (EIMs) are common in patients with Crohn's disease (CD). Various reactive cutaneous conditions, including erythema nodosum and pyoderma gangrenosum frequently occur as a part of EIMs. However, cutaneous metastasis of CD is rarely encountered in CD patients. Here, we report a 28-year-old female patient presenting with discharging deep fissures on genital and intergluteal regions. The result of a skin biopsy showed noncaseating granulomas. After rule out all the other differential diagnoses for granulomatou...
Source: Biomed Res - Category: Research Authors: Source Type: research
World J Gastroenterol. 2021 Dec 28;27(48):8201-8215. doi: 10.3748/wjg.v27.i48.8201.ABSTRACTS-palmitoylation is one of the most common post-translational modifications in nature; however, its importance has been overlooked for decades. Crohn's disease (CD), a subtype of inflammatory bowel disease (IBD), is an autoimmune disease characterized by chronic inflammation involving the entire gastrointestinal tract. Bowel damage and subsequent disabilities caused by CD are a growing global health issue. Well-acknowledged risk factors for CD include genetic susceptibility, environmental factors, such as a westernized lifestyle, and...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Source Type: research
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