The Genetic Architecture of Arsenic Metabolism Efficiency: A SNP-Based Heritability Study of Bangladeshi Adults

Conclusions: Our results suggest that there are common variants outside of the AS3MT region that influence arsenic metabolism in Bangladeshi individuals, but the effects of these variants are very weak compared to variants near AS3MT. The high heritability estimates observed using family-based heritability approaches suggest substantial effects for rare variants and/or unmeasured environmental factors. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Gao J, Tong L, Argos M, Scannell Bryan M, Ahmed A, Rakibuz-Zaman M, Kibriya MG, Jasmine F, Slavkovich V, Graziano JH, Ahsan H, Pierce BL. The Genetic Architecture of Arsenic Metabolism Efficiency: A SNP-Based Heritability Study of Bangladeshi Adults. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1408909. Received: 2 July 2014 Accepted: 11 March 2015 Advance Publication: 13 March 2015 EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you ne...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research