Leveraging the Intramural Research Program to Effect Foundational Progress in Neurodegenerative Disease

This is the annual G. Burroughs Mider Lecture. Speaker Andrew Singleton works on the genetic basis of neurological disorders including Parkinson's disease, Alzheimer ’ s disease, dystonia, ataxia, dementia with Lewy bodies, and amyotrophic lateral sclerosis (ALS). His team seeks to identify genetic variability that causes or contributes to disease and to use this knowledge to understand the underlying molecular processes. Most recently his work has expanded to the use of multimodal data in predicting disease. Dr. Singleton ’ s group discovered a number of genetic mutations that cause disease, including the alpha-synuclein multiplication mutation and mutations in LRRK2. Dr. Singleton was a founding member of the International Parkinson Disease Genomics Consortium, which has identified the majority of the known genetic risk factors for Parkinson disease.For more information go tohttps://oir.nih.gov/walsAir date: 3/30/2022 3:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video

Related Links:

A Correction to this paper has been published:https://doi.org/10.1007/s00330-021-07757-5
Source: European Radiology - Category: Radiology Source Type: research
Normal-pressure hydrocephalus (NPH) is characterized by the clinical triad of dementia, gait instability, and urinary incontinence. The estimated annual incidence is 1.8 cases in 100,000 persons, making NPH a rare diagnosis and uncommon cause of dementia. NPH is a form of communicating hydrocephalus that can easily be missed in older adults with multiple comorbidities, so clinicians must exclude reversible causes of dementia before diagnosing irreversible causes such as Alzheimer disease.
Source: Journal of the American Academy of Physician Assistants - Category: Primary Care Tags: Case Report Source Type: research
The Cambridge drugmaker has laid out ambitious plans for its FDA-required confirmatory trial of its Alzheimer's drug, Aduhelm. The plans include a diverse patient cohort, as well as new endpoints designed to rate patients' levels of cognitive impairment.
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
On your side, face-up or face-down? The position which best clears metabolic waste from your brain at night.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Sleep Source Type: blogs
Nine years before memory changes, this can signal problems.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
Condition:   Parkinson Disease Intervention:   Other: This is an observational study, there is no intervention in this study. Sponsors:   University of Haifa;   Rambam Health Care Campus Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Parkinson Disease Intervention:   Other: Smart-home for freezing of gait Sponsors:   University of Haifa;   Hebrew University of Jerusalem;   Technion, Israel Institute of Technology Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
I still remember the Christmas my sister was given one of the very first computer games as a gift from our parents. Plugged into our television it allowed us to play a virtual game of tennis, batting what I now know to be a collection of pixels against the sides of the screen, so it bounced randomly around. I must have been about 11 at the time and I still recall the recognition that something fundamental had changed about the world I lived in, although it was to be several decades later that I was able to articulate it in a way that made sense. That Christmas morning was a turning point; not just for me, but for all human...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Life digital wisdom Source Type: news
Abdulrahman Mohammed Abu-Yaman is the winner of the flash fiction category in the 2021 Hysteria Writing Competition. You can find his writing, along with the other finalists from each category in the Hysteria 8 anthology. Listen to the recording Read by Steve Graham during the Hysteria 8 launch party. https://lindaph.co.uk/wp-content/uploads/2022/01/Abdulrahman-Mohammed-Abu-Yaman.mp3 Read his entry Civilization begins in Egypt—our dear mother. Cairo, her cherub son, lounges atop the pyramid—on the spot where all the vertical borders intersect. Oriental Asia welcomes the sunrise. The sunshine flashes the limel...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Hysteria flash fiction hysteria 2021 hysteria 8 Source Type: news
THURSDAY, Jan. 27, 2022 -- Red wine may be a guilty pleasure, but new research shows it might also be a powerful weapon against the ravages of Parkinson's disease. Why? The antioxidants in red wine, and fruit such as berries for that matter, might...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
More News: ALS | Alzheimer's | Ataxia | Brain | Dementia | Dystonia | General Medicine | Genetics | Neurology | Parkinson's Disease