Leveraging the Intramural Research Program to Effect Foundational Progress in Neurodegenerative Disease
This is the annual G. Burroughs Mider Lecture. Speaker Andrew Singleton works on the genetic basis of neurological disorders including Parkinson's disease, Alzheimer ’ s disease, dystonia, ataxia, dementia with Lewy bodies, and amyotrophic lateral sclerosis (ALS). His team seeks to identify genetic variability that causes or contributes to disease and to use this knowledge to understand the underlying molecular processes. Most recently his work has expanded to the use of multimodal data in predicting disease. Dr. Singleton ’ s group discovered a number of genetic mutations that cause disease, including the alpha-synuclein multiplication mutation and mutations in LRRK2. Dr. Singleton was a founding member of the International Parkinson Disease Genomics Consortium, which has identified the majority of the known genetic risk factors for Parkinson disease.For more information go tohttps://oir.nih.gov/walsAir date: 3/30/2022 3:00:00 PM
A Correction to this paper has been published:https://doi.org/10.1007/s00330-021-07757-5
Normal-pressure hydrocephalus (NPH) is characterized by the clinical triad of dementia, gait instability, and urinary incontinence. The estimated annual incidence is 1.8 cases in 100,000 persons, making NPH a rare diagnosis and uncommon cause of dementia. NPH is a form of communicating hydrocephalus that can easily be missed in older adults with multiple comorbidities, so clinicians must exclude reversible causes of dementia before diagnosing irreversible causes such as Alzheimer disease.
The Cambridge drugmaker has laid out ambitious plans for its FDA-required confirmatory trial of its Alzheimer's drug, Aduhelm. The plans include a diverse patient cohort, as well as new endpoints designed to rate patients' levels of cognitive impairment.
On your side, face-up or face-down? The position which best clears metabolic waste from your brain at night.
Nine years before memory changes, this can signal problems.
Condition: Parkinson Disease Intervention: Other: This is an observational study, there is no intervention in this study. Sponsors: University of Haifa; Rambam Health Care Campus Active, not recruiting
Condition: Parkinson Disease Intervention: Other: Smart-home for freezing of gait Sponsors: University of Haifa; Hebrew University of Jerusalem; Technion, Israel Institute of Technology Recruiting
I still remember the Christmas my sister was given one of the very first computer games as a gift from our parents. Plugged into our television it allowed us to play a virtual game of tennis, batting what I now know to be a collection of pixels against the sides of the screen, so it bounced randomly around. I must have been about 11 at the time and I still recall the recognition that something fundamental had changed about the world I lived in, although it was to be several decades later that I was able to articulate it in a way that made sense. That Christmas morning was a turning point; not just for me, but for all human...
Abdulrahman Mohammed Abu-Yaman is the winner of the flash fiction category in the 2021 Hysteria Writing Competition. You can find his writing, along with the other finalists from each category in the Hysteria 8 anthology. Listen to the recording Read by Steve Graham during the Hysteria 8 launch party. https://lindaph.co.uk/wp-content/uploads/2022/01/Abdulrahman-Mohammed-Abu-Yaman.mp3 Read his entry Civilization begins in Egypt—our dear mother. Cairo, her cherub son, lounges atop the pyramid—on the spot where all the vertical borders intersect. Oriental Asia welcomes the sunrise. The sunshine flashes the limel...
THURSDAY, Jan. 27, 2022 -- Red wine may be a guilty pleasure, but new research shows it might also be a powerful weapon against the ravages of Parkinson's disease. Why? The antioxidants in red wine, and fruit such as berries for that matter, might...