Role of PLC γ1 in the modulation of cell migration and cell invasion in glioblastoma

This study aims to determine the pathological influence of PLCγ1 in glioblastoma, through a translational study which combines in silico data, data from glioblastoma patients' samples and data on engineered cell lines. We found out that PLCγ1 gene expression correlates with the pathological grade of gliomas, and it is higher in fifty patients' glioblastoma tissue samples compared to twenty healthy controls. Moreover, it was demonstrated that PLCγ1 silencing in U87-MG leads to a reduction in cell migration and invasion abilities. The opposite trend was observed following PLCγ1 overexpression, suggesting an interesting possible involvement of PLCγ1 in gliomas' aggressiveness.PMID:34819252 | DOI:10.1016/j.jbior.2021.100838
Source: Adv Data - Category: Epidemiology Authors: Source Type: research

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Mol Neurobiol. 2022 Jan 27. doi: 10.1007/s12035-021-02705-2. Online ahead of print.ABSTRACTEncephalitis mediated by autoantibodies against neuronal antigens and herpes simplex encephalitis (HSE) are seemingly separate causes of encephalopathy in adults. Autoimmune encephalitis (AE) is autoimmune in origin, and herpes simplex encephalitis is infectious. The purpose of this study was to examine the role of cerebrospinal fluid (CSF) exosomes from patients with antibody-positive AE and HSE. Towards this, exosomes were isolated from CSF from 13 patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, 11 patients w...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
ers Rosendal Korshoej Surgery is essential in the treatment of high-grade gliomas (HGG) and gross total resection (GTR) is known to increase the overall survival and progression-free survival. Several studies have shown that fluorescence-guided surgery with 5-aminolevulinic acid (5-ALA) increases GTR considerably compared to white light surgery (65% vs. 36%). In recent years, sodium fluorescein (SF) has become an increasingly popular agent for fluorescence-guided surgery due to numerous utility benefits compared to 5-ALA, including lower cost, non-toxicity, easy administration during surgery and a wide indication range...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Prog Brain Res. 2022;268(1):315-327. doi: 10.1016/bs.pbr.2021.10.039. Epub 2021 Dec 14.ABSTRACTGKNS for uveal melanoma has become a recognized valued treatment which avoids enucleation of the eye. In the early days, the eccentric location of these tumors made treatment difficult, but Gamma Knife Perfexion has solved that problem. It is known that larger tumors and tumors with an anterior location have a worse prognosis. GKNS has also been of rather unexpected benefit in optic nerve gliomas that require treatment. Choroidal hemangiomas may benefit from treatment as can secondary glaucoma. It has also been found to be benefi...
Source: Brain Research - Category: Neurology Authors: Source Type: research
Prog Brain Res. 2022;268(1):271-277. doi: 10.1016/bs.pbr.2021.10.036. Epub 2021 Dec 14.ABSTRACTLow grade gliomas concern grade I and grade II tumors. The only grade one tumor is the pilocytic astrocytoma. This is a well-defined tumor with characteristic histology, often accompanied by a cyst. GKNS has been used in surgically inaccessible tumors since 1994. More recently it has been demonstrated that the tumors are more treatment resistant in adults than in children. Grade II tumors include oligodendrogliomas and grade II diffuse astrocytomas. The standard treatment for oligodendrogliomas us total removal followed by fracti...
Source: Brain Research - Category: Neurology Authors: Source Type: research
Prog Brain Res. 2022;268(1):259-270. doi: 10.1016/bs.pbr.2021.10.035. Epub 2021 Dec 14.ABSTRACTGKNS has a limited role in the management of malignant gliomas. It has little or nothing to offer in primary treatment. However, there is evidence that with recurrent tumors which are 4cm in diameter or less, in younger patients, GKNS used together with bevacizumab can prolong overall survival. Nonetheless, more research is required to determine the precise role of the technique.PMID:35074084 | DOI:10.1016/bs.pbr.2021.10.035
Source: Brain Research - Category: Neurology Authors: Source Type: research
CONCLUSION: CfDNA levels showed good diagnostic discrimination in glioma, GBC, breast, lung carcinoma, and OSCC. Significant increase in titers was evident with increase in cancer stage from I to IV in breast, GBC and OSCC.PMID:35074971 | DOI:10.4103/IJPM.IJPM_474_20
Source: Indian Journal of Pathology and Microbiology - Category: Pathology Authors: Source Type: research
J Leukoc Biol. 2022 Jan 24. doi: 10.1002/JLB.5MA1221-468R. Online ahead of print.ABSTRACTPolypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts), a group of isoenzymes that initiate mucin-type O-glycosylation, have been shown to mediate tumor growth and metastasis in various cancer types. However, data on the clinical significance and features of GalNAc-Ts remain scant. Here, we used Oncomine and The Cancer Genome Atlas (TCGA) databases to analyze the transcription and survival effect of GALNTs (N-acetylgalactosaminyltransferase genes) in pan-cancer. The data showed that the GALNTs were aberrantly expressed in various h...
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Source Type: research
Ann Transl Med. 2021 Dec;9(24):1804. doi: 10.21037/atm-21-4760.ABSTRACTGliomas are one of the most common tumors of the central nervous system, which cause significant morbidity and mortality. Glioblastoma (GBM) is an aggressive and debilitating disease, which is the most common primary brain tumor in adults. Despite optimal surgical resection followed by radiotherapy and adjuvant chemotherapy, prognosis of patients with GBM remain poor. Tumor-treating fields (TTFields), as a novel treatment approach, is being explored through increased clinical application. Herein, we report the case of a 46-year-old man who was diagnosed...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
AbstractObjectivesTo evaluate the performance of velocity-selective (VS) ASL among patients with untreated gliomas by comparing with both pseudo-continuous (PC) ASL and dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI).MethodsForty-four consecutive patients with newly diagnosed glioma who underwent preoperative perfusion MRI including VSASL, PCASL, and DSC-PWI between 2017 and 2019 were retrospectively evaluated. Visual inspection was performed to evaluate the tumor signal intensity relative to gray matter based on 1 –5 score criteria and weighted kappa was used to evaluate the pair-wise c...
Source: European Radiology - Category: Radiology Source Type: research
ConclusionOur study found no significant decline in patient QOL or depression scores as assessed by patient- reported outcome measures for patients with low-grade glioma up to 2  years following surgery. We found no difference between RT + TMZ compared to observation during this time frame. Additional follow-up can help identify the longer-term impact of treatment strategy on patient experience.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
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