Role of PLC γ1 in the modulation of cell migration and cell invasion in glioblastoma

This study aims to determine the pathological influence of PLCγ1 in glioblastoma, through a translational study which combines in silico data, data from glioblastoma patients' samples and data on engineered cell lines. We found out that PLCγ1 gene expression correlates with the pathological grade of gliomas, and it is higher in fifty patients' glioblastoma tissue samples compared to twenty healthy controls. Moreover, it was demonstrated that PLCγ1 silencing in U87-MG leads to a reduction in cell migration and invasion abilities. The opposite trend was observed following PLCγ1 overexpression, suggesting an interesting possible involvement of PLCγ1 in gliomas' aggressiveness.PMID:34819252 | DOI:10.1016/j.jbior.2021.100838

Source: Adv Data - November 25, 2021 Category: Epidemiology Authors: Maria Vittoria Marvi Sara Mongiorgi Giulia Ramazzotti Matilde Y Follo Anna Maria Billi Matteo Zoli Diego Mazzatenta Luca Morandi Sofia Asioli Veronica Papa James A McCubrey Pann-Ghill Suh Lucia Manzoli Lucio Cocco Stefano Ratti Source Type: research