Lung transplantation for COVID-19 induced ARDS: a single-center experience
Conclusion: LT is feasible for COVID-19 induced ARDS and should be considered for carefully selected patients with irreversible lung injury.
Assessing the risk for specific patient groups to suffer from severe courses of COVID-19 is of major importance in the current SARS-CoV-2 pandemic. This review focusses on the risk for specific patient groups with chronic respiratory conditions, such as patients with asthma, chronic obstructive pulmonary disease, cystic fibrosis (CF), sarcoidosis, interstitial lung diseases, lung cancer, sleep apnea, tuberculosis, neuromuscular diseases, a history of pulmonary embolism, and patients with lung transplants. Evidence and recommendations are detailed in exemplary cases. While some patient groups with chronic respiratory condit...
Sao Paulo Med J. 2022 Jan-Feb;140(1):1-4. doi: 10.1590/1516-3180.2022.140126082021.NO ABSTRACTPMID:35043866 | DOI:10.1590/1516-3180.2022.140126082021
AbstractExtended duration extracorporeal membrane oxygenation (ECMO), using dual-lumen cannulas, is being used with increased frequency to support patients, including those with COVID-19; both as a bridge to transplant and lung recovery. During such an extended duration of support, there are several factors that might lead to the attrition of the physical structure of the ECMO cannulas, predisposing them to the risk of fracture. Although rare, fracture of the ECMO cannula can be a potentially lethal event. Here, we present a case where fracture of a dual lumen cannula during veno-venous (VV) ECMO support resulted in a cere...
In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment.
Two brand-new COVID-19 pills that were supposed to be an important weapon against the pandemic in the U.S. are in short supply and have played little role in the fight against the Omicron wave of infections. The problem is that production is not yet at full strength and that the pill considered to be far superior, Pfizer’s, takes six to eight months to manufacture. While the supply is expected to improve dramatically in the coming months, doctors are clamoring for the pills now, not just because Omicron is causing an explosion of cases but because two antibody drugs that were once the go-to treatments don’t wor...
Circ J. 2022 Jan 12. doi: 10.1253/circj.CJ-21-1048. Online ahead of print.NO ABSTRACTPMID:35022332 | DOI:10.1253/circj.CJ-21-1048
CONCLUSIONS: The major pathologic findings in the lung explants of patients with SARS-CoV-2 infection suggest ongoing fibrosis, prominent macrophage infiltration, neoangiogenesis, and microvascular thrombosis. Characterization of pathologic findings could help develop novel management strategies.PMID:34999755 | DOI:10.1093/ajcp/aqab208
In conclusion, the appropriate management of viral complications after transplantation remain an essential step to continue improving survival and quality of life of lung transplant recipients.PMID:34992844 | PMC:PMC8662465 | DOI:10.21037/jtd-2021-24