Near ‐Infrared II Plasmonic Phototheranostics with Glutathione Depletion for Multimodal Imaging‐Guided Hypoxia‐Tolerant Chemodynamic‐Photocatalytic‐Photothermal Cancer Therapy Triggered by a Single Laser

Near-infrared II (NIR-II) plasmonic phototheranostics, an “all-in-one” phototheranostic platform, is reported with plasmonic Au@Cu2 −xSe core-shell nanocrystals for photoacoustic-photothermal imaging-guided chemodynamic-photocatalytic-photothermal therapy all triggered by a single NIR-II laser. Tumor microenvironment-specific production of hydroxyl radials via Fenton-like reaction and photocatalytic reaction offers excellent therapeutic efficacy for cancer, achieving complete tumor eradication using a single NIR-II laser. AbstractTumor microenvironment (TME)-activatable phototheranostics is highly desirable in cancer management but still remains challenging for clinical applications owing to the lack of multifunctional theranostic agents and the limited tissue penetration depth. Reported here is an “all-in-one” phototheranostic platform based on near-infrared II (NIR-II) dual-plasmonic Au@Cu2 −xSe core-shell nanocrystals (dpGCS NCs) for combined photoacoustic (PA)/photothermal (PT) imaging-guided chemodynamic therapy (CDT)/photocatalytic therapy (PCT)/photothermal therapy (PTT) all triggered by a single NIR-II laser. The dpGCS NCs feature excellent NIR-II plasmonic and PT properties, which guarantee their capabilities of NIR-II PA and PT imaging for real-time visual observation of tumor size and location during cancer treatment. Additionally, the TME-activated in situ •OH production via dpGCS NC-catalyzed Fenton-like reaction is further enhanced by the NIR-II ir...
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research