Omega-3 fatty acids for depression in adults

CONCLUSIONS: At present, we do not have sufficient high-certainty evidence to determine the effects of n-3PUFAs as a treatment for MDD. Our primary analyses may suggest a small-to-modest, non-clinically beneficial effect of n-3PUFAs on depressive symptomology compared to placebo; however the estimate is imprecise, and we judged the certainty of the evidence on which this result is based to be low to very low. Our data may also suggest similar rates of adverse events and trial non-completion in n-3PUFA and placebo groups, but again our estimates are very imprecise. Effects of n-3PUFAs compared to antidepressants are very imprecise and uncertain. More complete evidence is required for both the potential positive and negative effects of n-3PUFAs for MDD.PMID:34817851 | DOI:10.1002/14651858.CD004692.pub5

Source: Cochrane Database of Systematic Reviews - November 24, 2021 Category: General Medicine Authors: Katherine M Appleton Philip D Voyias Hannah M Sallis Sarah Dawson Andrew R Ness Rachel Churchill Rachel Perry Source Type: research